Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, 97006, USA.
Division of Comparative Medicine, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.
Nat Commun. 2022 Jan 11;13(1):234. doi: 10.1038/s41467-021-27925-x.
Environmental enteric dysfunction is associated with malnutrition as well as infant growth stunting and has been classically defined by villous blunting, decreased crypt-to-villus ratio, and inflammation in the small intestine. Here, we characterized environmental enteric dysfunction among infant rhesus macaques that are naturally exposed to enteric pathogens commonly linked to human growth stunting. Remarkably, despite villous atrophy and histological abnormalities observed in the small intestine, poor growth trajectories and low serum tryptophan levels were correlated with increased histopathology in the large intestine. This work provides insight into the mechanisms underlying this disease and indicates that the large intestine may be an important target for therapeutic intervention.
环境肠道功能障碍与营养不良以及婴儿生长迟缓有关，其经典定义为小肠绒毛变钝、隐窝-绒毛比降低和炎症。在这里，我们描述了自然暴露于与人类生长迟缓相关的肠道病原体的幼年恒河猴中的环境肠道功能障碍。值得注意的是，尽管小肠观察到绒毛萎缩和组织学异常，但生长轨迹不良和血清色氨酸水平低与大肠组织病理学增加相关。这项工作提供了对该疾病潜在机制的深入了解，并表明大肠可能是治疗干预的重要靶点。
