Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
Iran J Med Sci. 2022 Jan;47(1):15-24. doi: 10.30476/ijms.2020.85941.1557.
Patients with beta-thalassemia (BT) are susceptible to psychological disorders such as depression. The present study was conducted to estimate the pooled prevalence of depression among patients with BT in Iran.
Domestic and international databases were searched for relevant articles published from 1991 until June 2019. We searched international databases such as Scopus, ISI, and Embase; Iranian databases such as SID, Magiran, and IranDoc; and Google Scholar and PubMed search engines. The MeSH keywords used were "depression", "mental health", "depressive disorder", "thalassemia", "beta-thalassemia major", "prevalence", "epidemiology", and "Iran". Relevant cross-sectional or cohort studies were included in the analysis. Cochran's test and the index were used to assess heterogeneity. The pooled prevalence and its 95% confidence interval (CI) were calculated using "metaprop" commands in Stata 14. In cases, where the statistic was greater than 50%, the random-effects model was used.
Eighteen eligible studies were included. The pooled prevalence of depression was 42% (95% CI: 33% to 52%), whereas the pooled prevalence of mild, moderate, severe, and extremely severe depression was 16% (95% CI: 11% to 22%), 13% (95% CI: 9% to 18%), 13% (95% CI: 9% to 17%), and 3% (95% CI: 0% to 8%), respectively. The pooled prevalence of depression in moderate- and high-quality studies was 45% (95% CI: 29% to 61%), and 39% (95% CI: 27% to 51%), respectively.
The high prevalence of depression highlights the urgent need for the establishment of interventions for the prevention, early detection, and treatment of depression among Iranian patients with BT.
β-地中海贫血（BT）患者易患抑郁症等心理障碍。本研究旨在评估伊朗 BT 患者的抑郁患病率。
检索了 1991 年至 2019 年 6 月期间发表的相关文章，包括国际数据库 Scopus、ISI 和 Embase；伊朗数据库 SID、Magiran 和 IranDoc；以及 Google Scholar 和 PubMed 搜索引擎。使用的 MeSH 关键词包括“depression”（抑郁）、“mental health”（心理健康）、“depressive disorder”（抑郁障碍）、“thalassemia”（地中海贫血）、“beta-thalassemia major”（重型β地中海贫血）、“prevalence”（患病率）、“epidemiology”（流行病学）和“iran”（伊朗）。纳入的分析包括横断面或队列研究。采用 Cochran's 检验和 指数评估异质性。采用 Stata 14 中的“metaprop”命令计算合并患病率及其 95%置信区间（CI）。当 统计量大于 50%时，采用随机效应模型。
纳入了 18 项符合条件的研究。抑郁的合并患病率为 42%（95%CI：33%至 52%），轻度、中度、重度和极重度抑郁的合并患病率分别为 16%（95%CI：11%至 22%）、13%（95%CI：9%至 18%）、13%（95%CI：9%至 17%）和 3%（95%CI：0%至 8%）。中、高质量研究中抑郁的合并患病率分别为 45%（95%CI：29%至 61%）和 39%（95%CI：27%至 51%）。
伊朗 BT 患者的抑郁患病率较高，这凸显了迫切需要针对该人群制定预防、早期发现和治疗抑郁的干预措施。
