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慢性吸食海洛因与慢性阻塞性肺疾病之间的关联。

The Association between Chronic Heroin Smoking and Chronic Obstructive Pulmonary Disease.

作者信息

Bitar Ahmad Naoras, Khan Amer Hayat, Sulaiman Syed Azhar Syed, Ali Irfhan Ali Bin Hyder, Khan Irfanullah

机构信息

Department of Clinical Pharmacy, Universiti Sains Malaysia, Gelugore 11800, Penang, Malaysia.

Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Jln Tun Hamdan Sheikh Tahir, 13200 Kepala Batas, Penang, Malaysia.

出版信息

J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1215-S1223. doi: 10.4103/jpbs.jpbs_353_21. Epub 2021 Nov 10.

Abstract

INTRODUCTION

Little is known about the correlation between chronic obstructive pulmonary disease (COPD) and heroin smoking. Heroin smoking is a recent underinvestigated problem. The goal of this study is to study the impact of heroin smoking among COPD patients.

METHODS

This is a descriptive clinical study. A combination of self-reporting questionnaires and data extraction tools were used to collect information during baseline tests, interviews, and follow-ups. Patients' medical, clinical, and socioeconomic history were recorded. Participants were recruited using random sampling from multiple centers.

RESULTS

Out of 1034 COPD patients, heroin smokers represented the vast majority of addiction cases ( = 133). Heroin smokers were leaner than non-addicts (19.78 ± 4.07 and 24.01 ± 5.6, respectively). The most common type of comorbidities among heroin smokers was emphysema (27%). Both the forced expiratory volume (FEV)/forced vital capacity ratio and FEV1% predicted were lower among heroin smokers than non-addicts (52.79 ± 12.71 and 48.54 ± 14.38, respectively). The majority of heroin smokers (55%) had advanced COPD, and at least 15% of heroin smokers suffered from frequent respiratory failure. The mean ± SD for COPD onset age among heroin smokers was 44.23 ± 5.72, and it showed a statistically significant correlation ( < 0.001).

CONCLUSION

Heroin smoking might be linked to the onset of COPD. Heroin smokers showed a significantrespiratory impairment compared to tobacco smokers of the same age group.

摘要

引言

关于慢性阻塞性肺疾病(COPD)与吸食海洛因之间的相关性知之甚少。吸食海洛因是一个近期未得到充分研究的问题。本研究的目的是探讨吸食海洛因对COPD患者的影响。

方法

这是一项描述性临床研究。在基线测试、访谈和随访期间,使用自我报告问卷和数据提取工具相结合的方式收集信息。记录患者的医疗、临床和社会经济病史。通过随机抽样从多个中心招募参与者。

结果

在1034例COPD患者中,吸食海洛因者占成瘾病例的绝大多数(n = 133)。吸食海洛因者比非成瘾者更瘦(分别为19.78±4.07和24.01±5.6)。吸食海洛因者中最常见的合并症类型是肺气肿(27%)。吸食海洛因者的用力呼气量(FEV)/用力肺活量比值和预测的FEV1%均低于非成瘾者(分别为52.79±12.71和48.54±14.38)。大多数吸食海洛因者(55%)患有晚期COPD,至少15%的吸食海洛因者经常发生呼吸衰竭。吸食海洛因者的COPD发病年龄的均值±标准差为44.23±5.72,且显示出统计学显著相关性(P < 0.001)。

结论

吸食海洛因可能与COPD的发病有关。与同年龄组的吸烟者相比,吸食海洛因者表现出明显的呼吸功能损害。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b18b/8687033/b132f6a3ffa9/JPBS-13-1215-g001.jpg

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