Razi Mohammed Ahsan, Siddiqui Shandar, Mahajan Ankit, Qamar Seema, Kumari Puja, Kumari Soni
Department of Periodontology, Hazaribag College of Dental Sciences and Hospital, Hazaribag, Jharkhand, India.
Pedodontics and Preventive Dentistry, Patna Health Care, Sabzibagh, Patna, Bihar, India.
J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1350-S1353. doi: 10.4103/jpbs.jpbs_161_21. Epub 2021 Nov 10.
Periodontal diseases are a group of inflammatory diseases causing alveolar bone loss and eventually leading to loss of teeth. The present study was evaluated the effectiveness of platelet-rich fibrin (PRF) in the treatment of intrabony defects with or without bone graft.
Thirty subjects with the presence of intrabony defects were enrolled. All subjects were included irrespective of age and gender. A questionnaire was prepared for extracting demographic and personal details of all the patients. William probe and moth mirror-tweezers set was used for carrying out clinical examination of all subjects. Random and unbiased division of all the subjects was done with ten patients in each group as follows: Group I: Subjects in which treatment was carried out using PRF with demineralized bone matrix, Group II: Subjects in which treatment was carried out using PRF alone, and Group III: Subjects in which treatment was carried in the form of open flap debridement (OFD). Pretreatment and posttreatment clinical variables were assessed which included plaque index (PI), gingival index (GI), probing depth (PD), relative attachment level (RAL), and gingival recession (GR) were assessed at baseline and 9 months postoperatively were calculated.
Mean PI among Group 1, Group 2, and Group 3 at baseline was 0.78, 0.8, and 0.84, respectively. Mean PI among Group 1, Group 2, and Group 3 at 9 months follow-up was 0.56, 0.55, and 0.72, respectively. Significant results were obtained while comparing the PI among the three study groups at follow-up. Mean GI among Group 1, Group 2, and Group 3 at baseline was 0.78, 0.8, and 0.84, respectively. Mean GI among Group 1, Group 2, and Group 3 at 9 months follow-up was 0.56, 0.55, and 0.72, respectively. Significant results were obtained while comparing the GI among the three study groups at follow-up. Significant difference was seen in PD, RAL, and GR from baseline to 9 months in all groups ( < 0.05).
PRF leads to significantly better improvement in the clinical parameters on follow-up in comparison to OFD alone in patients with the presence of intrabony defects.
牙周疾病是一组导致牙槽骨丧失并最终导致牙齿脱落的炎症性疾病。本研究评估了富血小板纤维蛋白（PRF）在治疗伴有或不伴有骨移植的骨内缺损中的有效性。
招募了30名存在骨内缺损的受试者。纳入所有受试者，不考虑年龄和性别。准备了一份问卷以提取所有患者的人口统计学和个人详细信息。使用威廉探针和口镜镊子套装对所有受试者进行临床检查。将所有受试者随机且无偏地分为三组，每组10名患者，如下：第一组：使用PRF和脱矿骨基质进行治疗的受试者；第二组：仅使用PRF进行治疗的受试者；第三组：采用开放式翻瓣清创术（OFD）进行治疗的受试者。评估治疗前和治疗后的临床变量，包括菌斑指数（PI）、牙龈指数（GI）、探诊深度（PD）、相对附着水平（RAL）和牙龈退缩（GR），在基线时进行评估，并计算术后9个月时的数值。
第一组、第二组和第三组在基线时的平均PI分别为0.78、0.8和0.84。在9个月随访时，第一组、第二组和第三组的平均PI分别为0.56、0.55和0.72。在随访时比较三个研究组之间的PI时获得了显著结果。第一组、第二组和第三组在基线时的平均GI分别为0.78、0.8和0.84。在9个月随访时，第一组、第二组和第三组的平均GI分别为0.56、0.55和0.72。在随访时比较三个研究组之间的GI时获得了显著结果。所有组从基线到9个月时，PD、RAL和GR均有显著差异（<0.05）。
对于存在骨内缺损的患者，与单独的OFD相比，PRF在随访时能使临床参数有显著更好的改善。
