Soumya S, Gaffoor M A Faisal, Samuel Anoop, Gopakumar Rethi, Girish C Sabari, Sajeena N C
Department of Conservative Dentistry and Endodontics, Noorul Islam College of Dental Sciences, Thiruvananthapuram, Kerala, India.
J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1448-S1451. doi: 10.4103/jpbs.jpbs_249_21. Epub 2021 Nov 10.
One of the most common organisms responsible for root canal failure even after the usage of intracanal medicament is . Newer medicaments with higher antibacterial efficacy against need to be analyzed.
The aim of this study was to compare the antibacterial property of bioactive glass (BAG) alone and its combination with chlorhexidine (CHX) against .
Eighty permanent maxillary single-rooted teeth were included in the study. These teeth were randomly divided into three groups of ten teeth each. Dentin blocks were prepared. After debris and smear layer removal, dentin blocks were inoculated with and incubated for 7 days for biofilm formation. Medications including BAG alone and combination of CHX with BAG were placed into the dentin blocks and incubated at 37°C for 72 h. Dentinal shavings were collected, and the mean bacterial count was recorded.
The comparison of colony-forming unit (CFU) counts was done using one-way analysis of variance, Tukey's post hoc test, and unpaired -test. The analysis was done using the Statistical Package for the Social Sciences version 20.0 for Windows.
Based on the CFU count obtained after 72 h, compared to the control group, both Group 1 and Group 2 reduced the bacterial load effectively. In comparison with Group 1, Group 2 (combination) was found to be more effective against .
It can be concluded that although BAG was effective against , its efficacy increased significantly in combination with CHX.
即使使用了根管内药物，导致根管治疗失败的最常见微生物之一是 。需要分析对 具有更高抗菌效力的新型药物。
本研究的目的是比较单独使用生物活性玻璃（BAG）及其与洗必泰（CHX）联合使用对 的抗菌性能。
本研究纳入80颗上颌恒单根牙。这些牙齿被随机分为三组，每组10颗牙。制备牙本质块。去除碎屑和玷污层后，将牙本质块接种 并培养7天以形成生物膜。将包括单独使用BAG以及CHX与BAG联合使用的药物放入牙本质块中，并在37°C下孵育72小时。收集牙本质碎屑，并记录平均细菌计数。
使用单因素方差分析、Tukey事后检验和非配对 检验对菌落形成单位（CFU）计数进行比较。使用适用于Windows的社会科学统计软件包20.0进行分析。
根据72小时后获得的CFU计数，与对照组相比，第1组和第2组均有效降低了细菌载量。与第1组相比，发现第2组（联合组）对 的效果更佳。
可以得出结论，虽然BAG对 有效，但其与CHX联合使用时疗效显著提高。
