• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Focal cerebral hypoperfusion and selective cognitive deficit in dementia of the Alzheimer type.

作者信息

Celsis P, Agniel A, Puel M, Rascol A, Marc-Vergnes J P

机构信息

LHEC-INSERM U 230, Toulouse, France.

出版信息

J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1602-12. doi: 10.1136/jnnp.50.12.1602.

DOI:10.1136/jnnp.50.12.1602
PMID:3501801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1032601/
Abstract

Regional cerebral blood flow was investigated using single photon emission computed tomography and xenon-133 intravenous injection in six patients with dementia of the Alzheimer type (DAT) with atypical focal clinical presentation, and in 20 age-matched healthy volunteers. The patients had a progressive and preponderant cognitive deficit and a focal hypoperfusion that correlated with the neuropsychological findings, whereas the average flow did not significantly differ from that of controls. The assessment of concordant haemodynamic and neuropsychological focal abnormalities could be useful in the diagnosis of atypical cases of DAT.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a18/1032601/ca71a995b6fa/jnnpsyc00559-0043-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a18/1032601/976db0c0bbfc/jnnpsyc00559-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a18/1032601/2b92f06f8c9f/jnnpsyc00559-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a18/1032601/ca71a995b6fa/jnnpsyc00559-0043-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a18/1032601/976db0c0bbfc/jnnpsyc00559-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a18/1032601/2b92f06f8c9f/jnnpsyc00559-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a18/1032601/ca71a995b6fa/jnnpsyc00559-0043-b.jpg

相似文献

1
Focal cerebral hypoperfusion and selective cognitive deficit in dementia of the Alzheimer type.
J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1602-12. doi: 10.1136/jnnp.50.12.1602.
2
Comparison of positron emission tomography, cognition, and brain volume in Alzheimer's disease with and without severe abnormalities of white matter.阿尔茨海默病中有无严重白质异常情况下正电子发射断层扫描、认知及脑容量的比较
J Neurol Neurosurg Psychiatry. 1996 Feb;60(2):158-67. doi: 10.1136/jnnp.60.2.158.
3
[Disorders of regional cerebrovascular circulation and neuropsychological findings in dementia of the Alzheimer type].
Nervenarzt. 1989 Mar;60(3):141-8.
4
Cognitive performance correlates with cerebrovascular impairments in multi-infarct dementia.
J Am Geriatr Soc. 1986 May;34(5):355-60. doi: 10.1111/j.1532-5415.1986.tb04318.x.
5
Brain perfusion abnormalities in Alzheimer's disease: comparison between patients with focal temporal lobe dysfunction and patients with diffuse cognitive impairment.阿尔茨海默病中的脑灌注异常：局灶性颞叶功能障碍患者与弥漫性认知障碍患者的比较。
J Neurol Neurosurg Psychiatry. 2001 Jan;70(1):22-7. doi: 10.1136/jnnp.70.1.22.
6
Lateral asymmetries in primary degenerative dementia of the Alzheimer type. A correlative study of cognitive, haemodynamic and EEG data, in relation with severity, age of onset and sex.阿尔茨海默型原发性退行性痴呆的侧别不对称性。一项关于认知、血流动力学和脑电图数据与严重程度、发病年龄及性别的相关性研究。
Cortex. 1990 Dec;26(4):585-96. doi: 10.1016/s0010-9452(13)80308-5.
7
Regional cerebral blood flow measurements in the diagnosis of dementia.
Aust N Z J Med. 1989 Oct;19(5):436-42. doi: 10.1111/j.1445-5994.1989.tb00301.x.
8
Xenon-133 SPECT-determined regional cerebral blood flow in Alzheimer's disease: what is typical?
J Neuropsychiatry Clin Neurosci. 1993 Fall;5(4):415-8. doi: 10.1176/jnp.5.4.415.
9
Regional Cerebral Blood Flow in [123]I-IMP Single-photon Emission Computed Tomography and the Wechsler Memory Scale-revised in Nondemented Elderly Subjects with Subjective Cognitive Impairment.主观认知障碍的非痴呆老年人中[123]I-碘代安非他明单光子发射计算机断层扫描的局部脑血流量与修订版韦氏记忆量表的关系
Intern Med. 2016;55(24):3571-3578. doi: 10.2169/internalmedicine.55.6725. Epub 2016 Dec 15.
10
Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience.利用动脉自旋标记磁共振成像测量阿尔茨海默病和轻度认知障碍中的脑灌注不足模式：初步经验
Radiology. 2005 Mar;234(3):851-9. doi: 10.1148/radiol.2343040197.

引用本文的文献

1
Alzheimer's Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?阿尔茨海默病淀粉样蛋白假说和抗体疗法：冰川消融？
Int J Mol Sci. 2024 Mar 31;25(7):3892. doi: 10.3390/ijms25073892.
2
Compound IMM-H004, a novel coumarin derivative, protects against CA1 cell loss and spatial learning impairments resulting from transient global ischemia.化合物IMM-H004是一种新型香豆素衍生物，可预防短暂性全脑缺血导致的CA1细胞丢失和空间学习障碍。
CNS Neurosci Ther. 2015 Mar;21(3):280-8. doi: 10.1111/cns.12364. Epub 2015 Jan 20.
3
Slowly progressive aphasia with striatal involvement.

本文引用的文献

1
Noninvasive regional cerebral blood flow measurements in dementia.痴呆症的无创性局部脑血流量测量
Arch Neurol. 1980 Jul;37(7):410-8. doi: 10.1001/archneur.1980.00500560040003.
2
Angular gyrus syndrome simulating Alzheimer's disease.模拟阿尔茨海默病的角回综合征。
Arch Neurol. 1982 Oct;39(10):616-20. doi: 10.1001/archneur.1982.00510220014003.
3
Biopsy-proved Alzheimer disease presenting as a right parietal lobe syndrome.经活检证实的阿尔茨海默病表现为右侧顶叶综合征。
伴有纹状体受累的缓慢进行性失语症。
Am J Alzheimers Dis Other Demen. 2002 Jan-Feb;17(1):18-22. doi: 10.1177/153331750201700107.
4
Relation of anosognosia to frontal lobe dysfunction in Alzheimer's disease.失认症与阿尔茨海默病额叶功能障碍的关系。
J Neurol Neurosurg Psychiatry. 1994 Jul;57(7):805-9. doi: 10.1136/jnnp.57.7.805.
5
The cerebral localization of neuropsychological impairment in Alzheimer's disease: a SPECT study.阿尔茨海默病神经心理学损害的脑定位：一项单光子发射计算机断层扫描研究
J Neurol. 1989 Mar;236(3):131-8. doi: 10.1007/BF00314327.
6
Cerebral perfusion patterns in vascular dementia of Binswanger type compared with senile dementia of Alzheimer type: a SPECT study.宾斯旺格型血管性痴呆与阿尔茨海默型老年痴呆的脑灌注模式比较：一项单光子发射计算机断层扫描研究
J Neurol. 1991 Oct;238(7):365-70. doi: 10.1007/BF00319853.
7
Cognition and cerebral blood flow in lateralised parkinsonism: lack of functional lateral asymmetries.偏侧帕金森病的认知与脑血流：缺乏功能性侧不对称
J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):783-6. doi: 10.1136/jnnp.54.9.783.
8
Dementia presenting with aphasia: clinical characteristics.以失语为表现的痴呆：临床特征
J Neurol Neurosurg Psychiatry. 1991 Jun;54(6):542-5. doi: 10.1136/jnnp.54.6.542.
9
Comparative assessment of the disorders of higher brain functions in various types of cerebral atrophy.
Neurosci Behav Physiol. 1991 Sep-Oct;21(5):465-8. doi: 10.1007/BF01200283.
Ann Neurol. 1982 Aug;12(2):186-8. doi: 10.1002/ana.410120210.
4
Slowly progressive aphasia without generalized dementia.缓慢进展性失语，无全面性痴呆。
Ann Neurol. 1982 Jun;11(6):592-8. doi: 10.1002/ana.410110607.
5
18F-2-deoxy-2-fluoro-D-glucose as a tracer in the positron emission tomographic study of senile dementia.18F-2-脱氧-2-氟-D-葡萄糖作为正电子发射断层扫描研究老年痴呆症的示踪剂。
Am J Psychiatry. 1982 Mar;139(3):352-3. doi: 10.1176/ajp.139.3.352.
6
A method for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations.一种根据惰性气体浓度发射计算机断层扫描计算局部脑血流量的方法。
J Comput Assist Tomogr. 1981 Oct;5(5):641-5. doi: 10.1097/00004728-198110000-00006.
7
Language disturbance. An initial symptom of cortical degenerations and dementia.语言障碍。皮质退化和痴呆的初始症状。
Arch Neurol. 1984 May;41(5):491-6. doi: 10.1001/archneur.1984.04050170037012.
8
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.阿尔茨海默病的临床诊断：美国国立神经疾病与中风研究所-阿尔茨海默病及相关疾病协会工作组在卫生与公众服务部阿尔茨海默病特别工作组主持下的报告。
Neurology. 1984 Jul;34(7):939-44. doi: 10.1212/wnl.34.7.939.
9
The fluorodeoxyglucose 18F scan in Alzheimer's disease and multi-infarct dementia.18F氟代脱氧葡萄糖扫描在阿尔茨海默病和多发梗死性痴呆中的应用
Arch Neurol. 1983 Nov;40(12):711-4. doi: 10.1001/archneur.1983.04050110029003.
10
Alzheimer's disease: focal cortical changes shown by positron emission tomography.阿尔茨海默病：正电子发射断层扫描显示的局灶性皮质改变
Neurology. 1983 Aug;33(8):961-5. doi: 10.1212/wnl.33.8.961.