Foster N L, Chase T N, Fedio P, Patronas N J, Brooks R A, Di Chiro G
Neurology. 1983 Aug;33(8):961-5. doi: 10.1212/wnl.33.8.961.
Local rates of cortical glucose metabolism were estimated by positron emission tomography in 13 right-handed patients with Alzheimer's disease. Individuals with disproportionate failure of language function had markedly diminished metabolism in the left frontal, temporal, and parietal regions. Patients with predominant visuo-constructive dysfunction evidenced a hypometabolic focus in the right parietal cortex. Patients with memory failure as the most apparent feature had no significant metabolic asymmetry in cortical regions. In all subjects, verbal competency generally correlated with metabolic activity in the left frontal and temporal areas, while visuo-constructive test performance was linked to glucose utilization in the right parietal lobe.
通过正电子发射断层扫描术对13名右利手阿尔茨海默病患者的局部皮质葡萄糖代谢率进行了评估。语言功能不成比例衰退的个体，其左侧额叶、颞叶和顶叶区域的代谢明显减弱。以视觉构建功能障碍为主的患者，其右侧顶叶皮质有代谢减低灶。以记忆障碍为最明显特征的患者，其皮质区域无明显的代谢不对称。在所有受试者中，语言能力一般与左侧额叶和颞叶区域的代谢活动相关，而视觉构建测试表现则与右侧顶叶的葡萄糖利用有关。
