Celsis P, Agniel A, Puel M, Le Tinnier A, Viallard G, Démonet J F, Rascol A, Marc-Vergnes J P
INSERM U 230, CHU PURPAN, Toulouse, France.
Cortex. 1990 Dec;26(4):585-96. doi: 10.1016/s0010-9452(13)80308-5.
Cognitive, haemodynamic and EEG lateral asymmetries have been quantified in 20 patients with Primary Degenerative Dementia (PDD) and in 20 age-matched normal volunteers. Normalized asymmetry scores were calculated from the data obtained with a test battery, with SPECT and with quantitative EEG. Significant correlations were found between cognitive, haemodynamic and EEG scores in patients but not in controls. The functional asymmetries correlated to the Mini Mental State (MMS) score, the lowest MMS values being observed in patients with right hemisphere predominant impairment. Besides, in these patients, a significant correlation was observed between age at onset and MMS score so that, in this subgroup only, the earlier the onset the more severe the disease. Finally, the prevalence of pronounced functional asymmetry seemed to be higher in our male patients. Our study shows that lateral asymmetries are frequent in patients with PDD and that preferential lateralization of the abnormalities should be given further attention, especially with regards to age, sex and overall severity.
对20例原发性退行性痴呆（PDD）患者和20名年龄匹配的正常志愿者进行了认知、血流动力学和脑电图（EEG）的不对称性量化研究。通过一套测试、单光子发射计算机断层扫描（SPECT）和定量脑电图获得的数据计算标准化不对称分数。在患者中发现认知、血流动力学和脑电图分数之间存在显著相关性，而在对照组中未发现。功能不对称与简易精神状态（MMS）评分相关，右半球为主的损害患者MMS值最低。此外，在这些患者中，发病年龄与MMS评分之间存在显著相关性，因此仅在该亚组中，发病越早疾病越严重。最后，明显的功能不对称在男性患者中的患病率似乎更高。我们的研究表明，PDD患者中不对称现象很常见，异常的优先侧化应得到进一步关注，尤其是在年龄、性别和总体严重程度方面。
