Yanase Y, Tango T, Okumura K, Tada T, Kawasaki T
Department of Pediatrics, Japanese Red Cross Medical Center, Tokyo.
Microbiol Immunol. 1987;31(7):701-10. doi: 10.1111/j.1348-0421.1987.tb03131.x.
Changes in the lymphocyte subsets of 13 patients with varicella, 5 with hand-foot-and-mouth disease, 4 with scarlet fever, 10 with measles and 20 with Kawasaki disease were examined by immunofluorescent flow cytometric analysis using monoclonal antibodies against lymphocyte cell surface antigens. The results were compared with those of age-matched normal controls. A significant increase in the percentage of Leu-2a positive (Leu-2a+) cells was shown during the early convalescence of varicella, scarlet fever and measles. A significant decrease in the percentage of Leu-3a+ cells during the acute phase was common to all the diseases examined, and a significant decrease of Leu-4+ cells was observed except in measles. As a result, a significant decrease in the Leu-3a+/Leu-2a+ ratio was common to all the diseases examined during the acute and/or early convalescent phases. Leu-M3+ cells increased significantly in varicella, scarlet fever, and Kawasaki disease. HLA-DR+ cells increased significantly in varicella and Kawasaki disease. No significant changes in the proportions of Leu-7+, Leu-10+, and 2H7+ cells were found throughout the course of all the diseases examined.
采用针对淋巴细胞表面抗原的单克隆抗体，通过免疫荧光流式细胞术分析，检测了13例水痘患者、5例手足口病患者、4例猩红热患者、10例麻疹患者和20例川崎病患者的淋巴细胞亚群变化。将结果与年龄匹配的正常对照进行比较。水痘、猩红热和麻疹恢复期早期，Leu - 2a阳性（Leu - 2a+）细胞百分比显著增加。所有受检疾病急性期Leu - 3a+细胞百分比均显著降低，除麻疹外，Leu - 4+细胞均显著减少。结果显示，所有受检疾病在急性期和/或恢复期早期，Leu - 3a+/Leu - 2a+比值均显著降低。水痘、猩红热和川崎病中Leu - M3+细胞显著增加。水痘和川崎病中HLA - DR+细胞显著增加。在所有受检疾病的整个病程中，未发现Leu - 7+、Leu - 10+和2H7+细胞比例有显著变化。
