抗 Pythium insidiosum 活性的 MSI-78、LL-37 和 Magainin-2 抗菌肽。
Anti-Pythium insidiosum activity of MSI-78, LL-37, and magainin-2 antimicrobial peptides.
机构信息
Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.
Pharmacology Postgraduate Program, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.
出版信息
Braz J Microbiol. 2022 Mar;53(1):509-512. doi: 10.1007/s42770-022-00678-5. Epub 2022 Jan 11.
Abstract
We investigated the anti-Pythium insidiosum activity of the antimicrobial peptides (AMPs) MSI-78, LL-37, and magainin-2. To detect the minimum inhibitory concentration (MIC), fourteen clinical strains were incubated with the AMPs following the CLSI M38-A2 protocol. All three AMPs showed antimicrobial activity with an MIC range of 20-80 mg/L against all strains. We concluded that the evaluated AMPs have great potential as anti-Pythium insidiosum agents, and their activity deserves to be more explored in further research. Antimicrobial peptides were tested against Pythium insidiosum, a microorganism that causes a difficult-to-treat disease in animals and humans. These peptides have been shown to be able to kill P. insidiosum and may be candidates for use in the treatment of this infection.
摘要
我们研究了抗菌肽（AMPs）MSI-78、LL-37 和 magainin-2 抗 Pythium insidiosum 的活性。为了检测最小抑菌浓度（MIC），根据 CLSI M38-A2 方案，将 14 株临床分离株与 AMPs 孵育。三种 AMP 对所有菌株均表现出抗菌活性，MIC 范围为 20-80mg/L。我们得出结论，评估的 AMP 具有作为抗 Pythium insidiosum 剂的巨大潜力，其活性值得在进一步的研究中进一步探索。抗菌肽已被测试用于对抗一种导致动物和人类难以治疗的疾病的微生物 Pythium insidiosum。这些肽已被证明能够杀死 P. insidiosum，可能是用于治疗这种感染的候选药物。
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