Institute of Synthetic Bioarchitectures, University of Natural Resources and Life Sciences, Vienna, Austria.
Institute of Safety and Risk Sciences (ISR), University of Natural Resources and Life Sciences, Vienna, Austria.
Integr Environ Assess Manag. 2022 Nov;18(6):1488-1499. doi: 10.1002/ieam.4577. Epub 2022 Feb 4.
The Insect Allies program of the Defense Advanced Research Projects Agency has already sparked scientific debate concerning technology assessment-related issues, among which the most prevalent is that of dual use. Apart from the issues concerning peaceful applications, the technology also provides the blueprint for a potential bioweapon. However, the combination of a virus-induced genetic modification of crop plants in the field using genetically modified insect vectors poses a greater risk than the hitherto existing use of genetically modified organisms. The technology's great depth of intervention allows a number of sources for hazard and a tendency towards high exposure, but it is also encumbered with notable deficits in knowledge. These issues call for a thorough technology assessment. This article aims to provide an initial characterization from a technology assessment perspective, focusing on potential sources of risk for this novel invasive environmental biotechnology at an early stage of research and development. Integr Environ Assess Manag 2022;18:1488-1499. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
美国国防高级研究计划局的昆虫联盟计划已经引发了与技术评估相关的科学争论，其中最普遍的是两用问题。除了与和平应用有关的问题外，该技术还为潜在的生物武器提供了蓝图。然而，利用基因改良昆虫载体在田间对作物进行病毒诱导的基因修饰的组合比迄今使用的基因改良生物体带来更大的风险。该技术的深度干预提供了许多危害源和高暴露的倾向，但也存在着明显的知识缺陷。这些问题需要进行彻底的技术评估。本文旨在从技术评估的角度进行初步描述，重点关注该新型入侵环境生物技术在研究和开发的早期阶段的潜在风险源。综合环境评估与管理 2022;18:1488-1499。©2022 作者。综合环境评估与管理由 Wiley 期刊有限责任公司代表环境毒理与化学学会（SETAC）出版。
