白细胞介素-1β和白细胞介素-1α刺激人滑膜细胞的N-乙酰-β-氨基葡萄糖苷酶活性。
Interleukin-1 beta and interleukin-1 alpha stimulate the N-acetyl-beta-glucosaminidase activity of human synovial cells.
作者信息
Clarris B J, Fraser J R, Ash P, Leizer T, Hamilton J A
机构信息
University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia.
出版信息
Rheumatol Int. 1987;7(6):271-5. doi: 10.1007/BF00270528.
The properties of synovial cells are altered in vitro by monocyte-macrophage polypeptides (monokines), and these changes could explain some of the properties of the inflamed synovium in rheumatoid disease. Purified monokines have become available only recently for testing on the target synovial cells. We report here that purified human interleukin (IL)-1 beta and recombinant human IL-1 alpha stimulate the extracellular activity of the lysosomal hydrolase, N-acetyl-beta-glucosaminidase (NAG), of human synovial fibroblast-like cells. In contrast, another monokine, synovial activator, does not increase the NAG activity. Thus NAG is another cellular activity which can be modulated by interleukin-1.
单核细胞 - 巨噬细胞多肽（单核因子）可在体外改变滑膜细胞的特性，这些变化可以解释类风湿病中炎症滑膜的一些特性。纯化的单核因子直到最近才能够用于对靶滑膜细胞进行检测。我们在此报告，纯化的人白细胞介素（IL）-1β和重组人IL-1α可刺激人滑膜成纤维样细胞溶酶体水解酶N - 乙酰 - β - 氨基葡萄糖苷酶（NAG）的细胞外活性。相比之下，另一种单核因子滑膜激活剂不会增加NAG活性。因此，NAG是另一种可被白细胞介素 - 1调节的细胞活性。
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