Department of Dermatology, 28781Dr Ram Manohar Lohia Hospital and PGIMER, New Delhi.
Trop Doct. 2022 Apr;52(2):293-297. doi: 10.1177/00494755211069440. Epub 2022 Jan 12.
Patients with Hansen's disease are liable to develop non-healing trophic ulcers. The aim of this study was to determine the efficacy of autologous platelet rich fibrin (PRF) applied at weekly intervals in the management of trophic ulcers. The mean age of the patients, duration and size of ulcer were 44.3 years, 7.4 months and 6.25cm respectively. After the third sessions of weekly dressing, there was a significant reduction in the ulcer area (p value = 0.015). All ulcers healed by a maximum of six weeks. No adverse events were noted. PRF thus seems a feasible, safe, simple and cost-effective treatment method.
麻风病患者容易发生难以愈合的营养性溃疡。本研究旨在确定自体富血小板纤维蛋白（PRF）每周应用一次在营养性溃疡管理中的疗效。患者的平均年龄、溃疡的持续时间和大小分别为 44.3 岁、7.4 个月和 6.25cm。经过三次每周换敷料后，溃疡面积有显著减少（p 值=0.015）。所有溃疡在最长 6 周内愈合。未观察到不良反应。因此，PRF 似乎是一种可行、安全、简单且具有成本效益的治疗方法。
