Nagaraju Umashankar, Sundar Priya K, Agarwal Priyanka, Raju Belliappa P, Kumar Mahesh
Department of Dermatology, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, India.
J Cutan Aesthet Surg. 2017 Jan-Mar;10(1):3-7. doi: 10.4103/JCAS.JCAS_17_16.
Non-healing trophic ulcers in Hansen's disease patients is one of the major causes for disability. It has been shown that autologous platelet-rich fibrin matrix (PRFM) is effective in healing chronic non-healing leg ulcers.
The objective of this study is to demonstrate the efficacy of autologous platelet-rich fibrin matrix (PRFM) in non-healing trophic ulcers in patients treated for Hansen's disease.
A prospective study.
An institution-based clinic.
Seven treated patients with Hansen's disease, with a mean age of 38.33 years, with nine non-healing trophic ulcer of more than 6 weeks duration.
Photographs were taken before treatment and at every subsequent sitting. Area and volume were calculated at baseline and every subsequent sitting till the closure was achieved.
The healthy ulcers were treated with PRFM at weekly intervals, repeated once a week for a maximum of five sittings as per requirement.
The mean percentage improvement in the area was 93.52%, and volume was 97.74% at the end of the second sitting. All ulcers closed by a maximum of five sittings. No adverse events were noted.
PRFM for the treatment of trophic ulcers in treated patients with Hansen's disease is a feasible, safe, simple and inexpensive method.
麻风病患者的难愈性营养性溃疡是导致残疾的主要原因之一。已有研究表明，自体富血小板纤维蛋白基质（PRFM）对治疗慢性难愈性腿部溃疡有效。
本研究旨在证明自体富血小板纤维蛋白基质（PRFM）对接受麻风病治疗患者的难愈性营养性溃疡的疗效。
一项前瞻性研究。
一家基于机构的诊所。
7例接受治疗的麻风病患者，平均年龄38.33岁，患有9处病程超过6周的难愈性营养性溃疡。
在治疗前及随后每次就诊时拍照。在基线时以及随后每次就诊直至溃疡愈合时计算面积和体积。
对健康的溃疡每周用PRFM治疗一次，根据需要每周重复一次，最多进行5次治疗。
第二次治疗结束时，面积的平均改善百分比为93.52%，体积为97.74%。所有溃疡最多经过5次治疗均愈合。未观察到不良事件。
PRFM治疗接受麻风病治疗患者的营养性溃疡是一种可行、安全、简单且廉价的方法。
