来自东方烟草“YNOTBS1”的二萜类化合物及其生物活性。
Diterpenes from oriental tobacco 'YNOTBS1' and their bioactivities.
作者信息
Peng Mengjie, Zhao Hongmei, Zhao Congqi, Lv Fen, Li Guangda, Wang Ge, Zhou Wenbing, Li Zhenjie, Zhao Zhengxiong, Zhang Ling, Xu Junju
机构信息
College of Tobacco Science, Yunnan Agricultural University, Kunming, China.
Key Laboratory of Medicinal Chemistry for Natural Resources, Chemistry School of Chemical Science and Technology, Yunnan University, Kunming, P.R. China.
出版信息
Nat Prod Res. 2023 May;37(9):1536-1543. doi: 10.1080/14786419.2021.2025367. Epub 2022 Jan 12.
Seven diterpenes including two new seco-cembranoid basmanoids A () and B (), and two new labdane basmadanes A () and B (), and three known compounds (-)-dehydro-nor-ambreinolid (), (13)-8-hydroxy-13-labden-12-one (), and 14,15,16-dinor-7-oxolabda-8-ene-13-oic acid () were isolated from oriental tobacco 'YNOTBS1'. Compounds - and showed anti-tobacco mosaic virus (TMV) activity with inhibition rates in the range of 30-69% at the concentration of 1 mg/mL. However, none of them exhibited any inhibitory effects against nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages and anti-proliferative activities against cancer cell lines SMMC-7721 and A-549.
从香料烟‘YNOTBS1’中分离得到7个二萜类化合物，包括2个新的裂环-西松烷型化合物basmanoids A（）和B（）、2个新的半日花烷型化合物basmadanes A（）和B（）以及3个已知化合物（-）-脱氢降龙涎香醇（）、（13）-8-羟基-13-拉丹-12-酮（）和14,15,16-去甲-7-氧代-拉达-8-烯-13-酸（）。化合物和在浓度为1mg/mL时表现出抗烟草花叶病毒（TMV）活性，抑制率在30%-69%之间。然而，它们对脂多糖（LPS）和干扰素-γ（IFN-γ）诱导的RAW 264.7小鼠巨噬细胞中一氧化氮（NO）的产生均无抑制作用，对癌细胞系SMMC-7721和A-549也无抗增殖活性。
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