Peng Rui, Luo Yufeng, Cui Qianling, Wang Jun, Li Lidong
School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China.
ACS Appl Bio Mater. 2020 Feb 17;3(2):1305-1311. doi: 10.1021/acsabm.9b01242. Epub 2020 Jan 22.
In recent years, phototherapeutic strategies including photodynamic therapy (PDT) and photothermal treatment (PTT) have attracted extensive interest in biological and medical applications. To achieve high efficiency in therapy, it is crucial to develop promising agents possessing synergistic PDT and PTT effects, especially those triggered by single-wavelength near-infrared (NIR) light. Herein, a low-bandgap fluorene-based conjugated oligomer OF-Green-N with a donor-acceptor-donor (D-A-D) structure was synthesized, which had a broad absorption in both the visible and NIR range. Upon irradiation by 808 nm laser, the oligomer displayed a good photothermal capacity with a conversion efficiency of 37.7%, together with simultaneous photodynamic behavior which produced reactive oxygen species. By incubation with , OF-Green-N was demonstrated to possess outstanding antibacterial activity owing to the synergistic effects of PDT/PTT. Moreover, its green fluorescence excited by 420 nm light also provides an opportunity for imaging-guided treatment.
近年来，包括光动力疗法（PDT）和光热疗法（PTT）在内的光治疗策略在生物和医学应用中引起了广泛关注。为了实现高效治疗，开发具有协同PDT和PTT效应的有前景的试剂至关重要，尤其是那些由单波长近红外（NIR）光触发的试剂。在此，合成了一种具有供体-受体-供体（D-A-D）结构的低带隙芴基共轭低聚物OF-Green-N，其在可见光和近红外范围内均有广泛吸收。在808 nm激光照射下，该低聚物表现出良好的光热能力，转换效率为37.7%，同时具有产生活性氧的光动力行为。通过与……孵育，由于PDT/PTT的协同作用，OF-Green-N被证明具有出色的抗菌活性。此外，其在420 nm光激发下的绿色荧光也为成像引导治疗提供了机会。
