Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.
Adv Mater. 2017 Aug;29(31). doi: 10.1002/adma.201700487. Epub 2017 Jun 19.
It is highly desired that satisfactory photoactive agents with ideal photophysical characteristics are explored for potent cancer phototherapeutics. Herein, bifunctional nanoparticles of low-bandgap donor-acceptor (D-A)-type conjugated-polymer nanoparticles (CP-NPs) are developed to afford a highly efficient singlet-to-triplet transition and photothermal conversion for near-infrared (NIR) light-induced photodynamic (PDT)/photothermal (PTT) treatment. CP-NPs display remarkable NIR absorption with the peak at 782 nm, and perfect resistance to photobleaching. Photoexcited CP-NPs undergo singlet-to-triplet intersystem crossing through charge transfer in the excited D-A system and simultaneous nonradiative decay from the electron-deficient electron acceptor isoindigo derivative under single-wavelength NIR light irradiation, leading to distinct singlet oxygen quantum yield and high photothermal conversion efficiency. Moreover, the CP-NPs display effective cellular uptake and cytoplasmic translocation from lysosomes, as well as effective tumor accumulation, thus promoting severe light-triggered damage caused by favorable reactive oxygen species (ROS) generation and potent hyperthermia. Thus, CP-NPs achieve photoactive cell damage through their photoconversion ability for synergistic PDT/PTT treatment with tumor ablation. The proof-of-concept design of D-A-type conjugated-polymer nanoparticles with ideal photophysical characteristics provides a general approach to afford potent photoactive cancer therapy.
人们非常希望探索具有理想光物理特性的满意光活性剂，以用于有效的癌症光疗。在此，开发了具有低带隙给体-受体（D-A）型共轭聚合物纳米粒子（CP-NPs）的双功能纳米粒子，以提供高效的单重态到三重态跃迁和近红外（NIR）光诱导光动力（PDT）/光热（PTT）治疗的光热转换。CP-NPs 在 782nm 处显示出显著的近红外吸收峰，并且对光漂白具有完美的抵抗力。光激发的 CP-NPs 通过受激 D-A 系统中的电荷转移和单波长近红外光照射下从电子缺电子异吲哚衍生物的非辐射衰减经历单重态到三重态系间窜跃，导致明显的单线态氧量子产率和高光热转换效率。此外，CP-NPs 显示出有效的细胞摄取和从溶酶体中的细胞质易位，以及有效的肿瘤积累，从而促进由有利的活性氧（ROS）生成和强大的高热引起的严重光触发损伤。因此，CP-NPs 通过其光转化能力实现光活性细胞损伤，用于协同 PDT/PTT 治疗以消融肿瘤。具有理想光物理特性的 D-A 型共轭聚合物纳米粒子的概念验证设计为提供了一种有效的癌症治疗方法。
