Hu Sophia, Primavera Rosita, Razavi Mehdi, Avadhani Anirudh, Wang Jing, Thakor Avnesh S
Interventional Regenerative Medicine and Imaging Laboratory, Department of Radiology, Stanford University, Palo Alto, California 94304, United States.
Biionix (Bionic Materials, Implants & Interfaces) Cluster, Department of Internal Medicine, College of Medicine, University of Central Florida, Orlando, Florida 32827, United States.
ACS Appl Bio Mater. 2020 Oct 19;3(10):6626-6632. doi: 10.1021/acsabm.0c00725. Epub 2020 Sep 23.
Type-1 diabetes (T1D) is caused by immune-mediated destruction of insulin-producing beta-cells, resulting in insulin deficiency and hyperglycemia. Islet transplantation is a potential treatment for T1D, but clinical implementation is hampered by islet availability and poor islet survival post-transplantation. To overcome these issues, we developed an intravascular multiside hole catheter with an interior polydimethylsiloxane (PDMS) bioscaffold capable of housing a cellular cargo. We used computational fluid dynamics to determine an optimized catheter design, which we then fabricated. Using our hybrid PDMS bioscaffold-intravascular catheter, we demonstrated that this platform can successfully maintain islet function and viability.
1型糖尿病（T1D）是由免疫介导的胰岛素分泌β细胞破坏引起的，导致胰岛素缺乏和高血糖。胰岛移植是T1D的一种潜在治疗方法，但临床应用受到胰岛可用性和移植后胰岛存活率低的阻碍。为了克服这些问题，我们开发了一种带有内部聚二甲基硅氧烷（PDMS）生物支架的血管内多侧孔导管，该生物支架能够容纳细胞载体。我们使用计算流体动力学来确定优化的导管设计，然后进行制造。使用我们的混合PDMS生物支架-血管内导管，我们证明了该平台能够成功维持胰岛功能和活力。
