Han Jingjing, Yoon Juyoung
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
ACS Appl Bio Mater. 2020 Nov 16;3(11):7344-7351. doi: 10.1021/acsabm.0c01127. Epub 2020 Oct 19.
The nanozyme concept appeals to numerous scientists with interest in cancer catalytic therapy based on an easy and economic preparation with highly catalytic and stable properties compared to a natural enzyme. The supramolecular nanozyme is an especially efficient and simple method, which has been successful in biomedical applications by changing the redox state and reactive oxygen species in a cancer environment. Representative examples of nanozymes and supramolecular nanozymes in cancer catalytic therapy with respect to construction and development are displayed in this review. Emphasis is also placed on the supramolecular nanozyme materials and the inherent structure of those containing nanoparticles, hydrogels, nanovesicles, and the catalytic mechanism and reaction. The supramolecular nanozyme, promising for its special properties of selectivity, high catalytic capability and stability, could reveal the mysterious properties of the enzyme itself, and the efficient inhibition of the signaling channel in cancer catalytic therapy.
纳米酶概念吸引了众多对基于癌症催化疗法感兴趣的科学家，因为与天然酶相比，它的制备简便且经济，具有高催化性和稳定性。超分子纳米酶是一种特别高效且简单的方法，它通过改变癌症环境中的氧化还原状态和活性氧物种，在生物医学应用中取得了成功。本文综述了纳米酶和超分子纳米酶在癌症催化疗法中关于构建与发展的代表性实例。同时也重点介绍了超分子纳米酶材料以及那些包含纳米颗粒、水凝胶、纳米囊泡的材料的固有结构，还有催化机制和反应。超分子纳米酶因其选择性、高催化能力和稳定性等特殊性质而颇具前景，它能够揭示酶本身的神秘特性，并在癌症催化疗法中有效抑制信号通道。
