Duo Yanhong, Suo Meng, Zhu Daoming, Li Zihuang, Zheng Zheng, Tang Ben Zhong
Department of Radiation Oncology, The Second Clinical Medical College of Jinan University, 1st Affiliated Hospital of Southern University of Science and Technology, Shenzhen People's Hospital, Shenzhen 518020, China.
Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm 17177, Sweden.
ACS Appl Mater Interfaces. 2022 May 11;14(23):26394-403. doi: 10.1021/acsami.2c04210.
Relative to traditional photosensitizer (PS) agents, those that exhibit aggregation-induced emission (AIE) properties offer key advantages in the context of photodynamic therapy (PDT). At present, PDT efficacy is markedly constrained by the hypoxic microenvironment within tumors and the limited depth to which lasers can penetrate in a therapeutic context. Herein, we developed platelet-mimicking MnO nanozyme/AIEgen composites (PMD) for use in the interventional PDT treatment of hypoxic tumors. The resultant biomimetic nanoparticles (NPs) exhibited excellent stability and were able to efficiently target tumors. Moreover, they were able to generate O within the tumor microenvironment owing to their catalase-like activity. Notably, through an interventional approach in which an optical fiber was introduced into the abdominal cavity of mice harboring orthotopic colon tumors, good PDT efficacy was achieved. We thus propose that a novel strategy consisting of a combination of an AIEgen-based bionic nanozyme and a biomimetic cell membrane coating represents an ideal therapeutic platform for targeted antitumor PDT. This study is the first to have combined interventional therapy and AIEgen-based PDT, thereby overcoming the limited light penetration that typically constrains the therapeutic efficacy of this technique, highlighting a promising new AIEgen-based PDT treatment strategy.
相对于传统的光敏剂（PS），具有聚集诱导发光（AIE）特性的光敏剂在光动力疗法（PDT）方面具有关键优势。目前，肿瘤内的缺氧微环境以及激光在治疗环境中的有限穿透深度显著限制了PDT的疗效。在此，我们开发了用于缺氧肿瘤介入性PDT治疗的仿血小板MnO纳米酶/AIEgen复合材料（PMD）。所得的仿生纳米颗粒（NP）表现出优异的稳定性，并且能够有效地靶向肿瘤。此外，由于其类过氧化氢酶活性，它们能够在肿瘤微环境中产生O。值得注意的是，通过将光纤引入患有原位结肠肿瘤的小鼠腹腔的介入方法，实现了良好的PDT疗效。因此，我们提出一种由基于AIEgen的仿生纳米酶和仿生细胞膜涂层组合而成的新策略，代表了一种理想的靶向抗肿瘤PDT治疗平台。本研究首次将介入治疗与基于AIEgen的PDT相结合，从而克服了通常限制该技术治疗效果的有限光穿透问题，突出了一种基于AIEgen的有前景的新PDT治疗策略。
