Liu Chang, Leon-Plata Paola, Zaroudi Maryam, Dusza Mateusz, Lee Chun-Yin, Liu Ying
ACS Appl Bio Mater. 2020 Nov 16;3(11):7357-7362. doi: 10.1021/acsabm.0c00992. Epub 2020 Oct 21.
We report a particulate cell delivery platform, toroidal spiral particles (TSPs), for continuous cell activation, expansion, and local sustained release. Biocompatible TSPs, generated by a self-assembly process of polymeric droplet sedimentation in an aqueous solution and subsequent polymer solidification, possess many engineering design flexibilities to manipulate the microenvironment of the cells to control cell proliferation, migration, and release kinetics. These millimeter-size particles with desired mechanical and physicochemical properties may be potentially used for adoptive cellular therapy (ACT) delivery by a minimally invasive procedure to the tumor mass.
我们报告了一种用于细胞持续激活、扩增和局部持续释放的颗粒细胞递送平台——环形螺旋颗粒（TSPs）。生物相容性TSPs通过聚合物液滴在水溶液中自组装沉淀及随后的聚合物固化过程生成，具有许多工程设计灵活性，可操纵细胞微环境以控制细胞增殖、迁移和释放动力学。这些具有所需机械和物理化学性质的毫米级颗粒可能潜在地用于通过微创程序将过继性细胞疗法（ACT）递送至肿瘤块。
