Lee Jung Ho, Baek Seung Mi, Lee Gibum, Kim Seong-Jong, Kim Hyoung Seop, Hahn Sei Kwang
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Kyungbuk 790-784, Korea.
ACS Appl Bio Mater. 2020 Dec 21;3(12):8879-8889. doi: 10.1021/acsabm.0c01179. Epub 2020 Nov 18.
Magnesium (Mg) and its alloys have presented a paradigm for biodegradability in the field of biomedical devices. However, biodegradation of Mg and its alloys cause the formation of hydrogen gas and basic molecules in the body. Here we developed a surface modification method for Mg implants by double-coating with osteogenic dexamethasone (Dex)-loaded black phosphorus (BP) and poly(lactide--glycolide) (PLGA). According to electrochemical and biodegradation tests, the prepared Mg-Dex/BP/PLGA showed remarkably enhanced resistance against corrosion possibly by the neutralization of basic molecules from Mg implants with acidic molecules from BP and PLGA with increasing biodegradation. Scanning electron microscopy, cell proliferation tests, Alizarin Red staining, and alkaline phosphatase activity tests confirmed that MC3T3-E1 cells significantly proliferated and were differentiated on the Mg-Dex/BP/PLGA surface. Taken together, the facile surface modification of Mg implants could be effectively harnessed for protecting the Mg surface from corrosion and inducing the osseointegration of preosteoblasts onto the Mg implant.
镁（Mg）及其合金在生物医学设备领域已成为生物可降解性的典范。然而，镁及其合金的生物降解会在体内导致氢气和碱性分子的形成。在此，我们开发了一种用于镁植入物的表面改性方法，即通过负载成骨地塞米松（Dex）的黑磷（BP）和聚（丙交酯-乙交酯）（PLGA）进行双层涂层。根据电化学和生物降解测试，制备的Mg-Dex/BP/PLGA随着生物降解的增加，可能通过用来自BP和PLGA的酸性分子中和镁植入物中的碱性分子，从而显著增强了抗腐蚀能力。扫描电子显微镜、细胞增殖测试、茜素红染色和碱性磷酸酶活性测试证实，MC3T3-E1细胞在Mg-Dex/BP/PLGA表面显著增殖并分化。综上所述，镁植入物的这种简便表面改性可有效地用于保护镁表面免受腐蚀，并诱导前成骨细胞在镁植入物上的骨整合。
