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用于管理气道疾病重塑和炎症的先进治疗传递系统的概念。

Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases.

机构信息

School of Bioengineering & Biosciences, Lovely Professional University, Phagwara, Punjab, 144411, India.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.

出版信息

Future Med Chem. 2022 Feb;14(4):271-288. doi: 10.4155/fmc-2021-0081. Epub 2022 Jan 12.

DOI:10.4155/fmc-2021-0081
PMID:35019757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8890134/
Abstract

Chronic respiratory disorders affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.

摘要

慢性呼吸疾病影响着全球数百万人。正常气道壁结构的病理生理变化，包括其细胞和分子成分的组成和组织的变化，被称为气道重塑。由于缺乏有效的治疗策略和新型疗法来治疗和管理慢性呼吸道疾病，这给这些疾病的临床管理带来了严重的障碍。先进的药物输送技术的进步为对抗气道重塑的新出现的并发症提供了额外的优势。本综述旨在解决当前关于气道重塑的知识空白，包括重塑、炎症、临床表型之间的关系以及使用新型药物输送方法的意义。

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