Sabiston D, Tessler H, Sumers K, Osterle C, Cheetham J K, Duzman E, DeGryse R
University of Illinois at Chicago, College of Medicine.
Ophthalmic Surg. 1987 Dec;18(12):873-7.
In this double-masked clinical trial, 72 patients undergoing cataract extraction surgery received a topical loading dose of 0.03% flurbiprofen or vehicle before surgery and one drop four times daily for 2 weeks after surgery. The severity of conjunctival hyperemia, aqueous humor cells, and aqueous humor flare was lower in the flurbiprofen-treated group than in the vehicle-treated group at all follow-up visits; the differences were significant on day 14. Four patients treated with flurbiprofen and two treated with vehicle exhibited postoperative hyphemas. Treatment with flurbiprofen appeared to decrease the severity of inflammation following cataract extraction surgery.
在这项双盲临床试验中，72例接受白内障摘除手术的患者在手术前接受了0.03%氟比洛芬或赋形剂的局部负荷剂量，术后2周每天4次，每次1滴。在所有随访中，氟比洛芬治疗组的结膜充血、房水细胞和房水闪光的严重程度均低于赋形剂治疗组；在第14天差异显著。4例接受氟比洛芬治疗的患者和2例接受赋形剂治疗的患者出现术后前房积血。氟比洛芬治疗似乎降低了白内障摘除手术后的炎症严重程度。
