Wang Jin-Min, Yang Kan-Di, Wu Song-Ying, Zou Xiang-Gu, Liao Yuan-Sheng, Yang Bin, Xie Bu-Ni, Huang Yan, Li Shi-Ju, Ma Hui-Jun
Department of Internal Neurology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, 350003, Fujian, People's Republic of China.
Department of Internal Neurology, Anxi County Hospital, Quanzhou, Fujian, 362400, People's Republic of China.
Int J Gen Med. 2022 Jan 6;15:243-251. doi: 10.2147/IJGM.S338558. eCollection 2022.
This study aims to investigate the correlation of platelet parameters and C-reactive protein (CRP) with depression.
The clinical data of 61 patients with depression and 30 healthy control subjects were collected to compare the platelet parameters, CRP levels, and Hamilton Depression Rating Scale (HAMD) scores of the two groups for correlation analysis.
The results revealed that the body mass index (BMI) of patients with depression was lower (P < 0.05) than that of the healthy control subjects, and that this difference was more significant in women than in men. Patients with severe depression showed an increased mean platelet volume (MPV) (P < 0.05). In the patients with depression, MPV was positively correlated (P < 0.05) with HAMD scores for work and interest, gastrointestinal symptoms, hopelessness, the anxiety/somatization factor, and the hopelessness factor. Platelet count (PLT) was negatively correlated (P < 0.05) with HAMD scores for hypochondriasis, and plateletcrit (PCT) was negatively correlated (P < 0.05) with HAMD scores for middle insomnia and hypochondriasis. Platelet distribution width (PDW) was positively correlated (P < 0.05) with HAMD scores for gastrointestinal and systemic symptoms as well as hopelessness. Higher CRP levels (P < 0.05) were found in the patients with depression than in the healthy control subjects. Furthermore, in the patients with depression, CRP levels were positively correlated (P < 0.05) with HAMD scores for guilt and the cognitive impairment factor.
Classical platelet parameters (PLT, MPV, PCT, PDW) and CRP were shown to be associated with specific depressive symptoms and cognitive impairment factors, including sleep, gastrointestinal symptoms, hypochondriasis, losing interest in work, and despair. These results suggest that both platelet parameters and CRP could be suitable biomarkers for predicting the occurrence and prognosis of depression, thus providing a new target for its treatment.
本研究旨在探讨血小板参数及C反应蛋白（CRP）与抑郁症之间的相关性。
收集61例抑郁症患者和30例健康对照者的临床资料，比较两组的血小板参数、CRP水平及汉密尔顿抑郁量表（HAMD）评分，进行相关性分析。
结果显示，抑郁症患者的体重指数（BMI）低于健康对照者（P<0.05），且女性差异比男性更显著。重度抑郁症患者的平均血小板体积（MPV）升高（P<0.05）。在抑郁症患者中，MPV与HAMD工作和兴趣、胃肠道症状、绝望感、焦虑/躯体化因子及绝望感因子评分呈正相关（P<0.05）。血小板计数（PLT）与HAMD疑病症状评分呈负相关（P<0.05），血小板压积（PCT）与HAMD中度失眠和疑病症状评分呈负相关（P<0.05）。血小板分布宽度（PDW）与HAMD胃肠道和全身症状及绝望感评分呈正相关（P<0.05）。抑郁症患者的CRP水平高于健康对照者（P<0.05）。此外，在抑郁症患者中，CRP水平与HAMD内疚感及认知障碍因子评分呈正相关（P<0.05）。
经典血小板参数（PLT、MPV、PCT、PDW）及CRP与特定抑郁症状及认知障碍因子相关，包括睡眠、胃肠道症状、疑病症状、对工作失去兴趣及绝望感。这些结果表明，血小板参数及CRP均可能是预测抑郁症发生及预后的合适生物标志物，从而为抑郁症治疗提供新靶点。
