Chen Si-Han, Bu Xian-Le, Jin Wang-Sheng, Shen Lin-Lin, Wang Jun, Zhuang Zheng-Qian, Zhang Tao, Zeng Fan, Yao Xiu-Qing, Zhou Hua-Dong, Wang Yan-Jiang
Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Yuzhong District, Chongqing, China.
Medicine (Baltimore). 2017 May;96(21):e6843. doi: 10.1097/MD.0000000000006843.
Alzheimer disease (AD) has been made a global priority for its multifactorial pathogenesis and lack of disease-modifying therapies. We sought to investigate the changes of profile of blood routine in AD and its correlation with the disease severity.In all, 92 AD patients and 84 age and sex-matched normal controls were enrolled and their profiles of blood routine were evaluated.Alzheimer disease patients had increased levels of mean corpuscular hemoglobin, mean corpuscular volume, red cell distribution width-standard deviation, mean platelet volume,and decreased levels of platelet distribution width, red blood cell, hematocrit, hemoglobin, lymphocyte, and basophil compared with normal controls.Alterations in quantity and quality of blood cells may be involved in the pathogenesis of AD and contribute to the disease progression.
阿尔茨海默病（AD）因其多因素发病机制以及缺乏疾病修饰疗法而成为全球重点关注对象。我们旨在研究AD患者血常规指标的变化及其与疾病严重程度的相关性。总共纳入了92例AD患者和84例年龄及性别匹配的正常对照者，并对他们的血常规指标进行了评估。与正常对照者相比，AD患者的平均红细胞血红蛋白含量、平均红细胞体积、红细胞分布宽度标准差、平均血小板体积升高，而血小板分布宽度、红细胞、血细胞比容、血红蛋白、淋巴细胞和嗜碱性粒细胞水平降低。血细胞数量和质量的改变可能参与了AD的发病机制并促进疾病进展。
