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Mitochondria shape neutrophils during hypoxia.

作者信息

Kaplan Mariana J

机构信息

National Institute of Arthritis and Musculoskeletal and Skin Diseases.

出版信息

Blood. 2022 Jan 13;139(2):159-160. doi: 10.1182/blood.2021013440.

DOI:10.1182/blood.2021013440
PMID:35024809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8759528/
Abstract
摘要

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Mitochondria shape neutrophils during hypoxia.缺氧时线粒体塑造中性粒细胞。
Blood. 2022 Jan 13;139(2):159-160. doi: 10.1182/blood.2021013440.
2
Intermittent hypobaric hypoxia increases the ability of neutrophils to generate superoxide anion in humans.
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Prolonged exposure to hypoxia induces an autophagy-like cell survival program in human neutrophils.长期缺氧暴露可诱导人中性粒细胞发生自噬样细胞存活程序。
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4
[Cytochemical study of the carbohydrate metabolism of phagocytes during hypoxia].
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Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity.缺氧诱导的中性粒细胞存活由HIF-1α依赖性NF-κB活性介导。
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Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis.中性粒细胞中线粒体的功能特性：仅限于凋亡的作用。
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7
Immunometabolism: Oxygen sensing and cell metabolism in inflammation.
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Effects of oxygen tension and pH on the respiratory burst of human neutrophils.氧张力和pH值对人中性粒细胞呼吸爆发的影响。
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Sensors, transmitters, and targets in mitochondrial oxygen shortage-a hypoxia-inducible factor relay story.线粒体缺氧中的传感器、递质和靶标——一个缺氧诱导因子传递的故事。
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Phorbol 12-myristate 13-acetate stimulation under hypoxia induces nuclear swelling with DNA outflow but not extracellular trap formation of neutrophils.在低氧条件下，佛波醇 12-肉豆蔻酸 13-醋酸酯的刺激会导致中性粒细胞的核肿胀和 DNA 外流，但不会导致细胞外陷阱的形成。
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引用本文的文献

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study: HIF-1α-dependent glycolysis enhances NETosis in hypoxic conditions.研究：缺氧诱导因子-1α依赖性糖酵解增强缺氧条件下的中性粒细胞胞外诱捕网形成
Front Immunol. 2025 Apr 28;16:1583587. doi: 10.3389/fimmu.2025.1583587. eCollection 2025.
2
Metabolism: a potential regulator of neutrophil fate.代谢：中性粒细胞命运的潜在调节因子。
Front Immunol. 2024 Dec 4;15:1500676. doi: 10.3389/fimmu.2024.1500676. eCollection 2024.
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Novel energy optimizer, meldonium, rapidly restores acute hypobaric hypoxia-induced brain injury by targeting phosphoglycerate kinase 1.

本文引用的文献

1
Neutrophil HIF-1α stabilization is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle.中性粒细胞的 HIF-1α 稳定性通过甘油 3-磷酸穿梭产生的线粒体 ROS 得到增强。
Blood. 2022 Jan 13;139(2):281-286. doi: 10.1182/blood.2021011010.
2
Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD to alleviate mitochondrial disease.甘油-3-磷酸生物合成将细胞质 NAD 再生以减轻线粒体疾病。
Cell Metab. 2021 Oct 5;33(10):1974-1987.e9. doi: 10.1016/j.cmet.2021.06.013. Epub 2021 Jul 15.
3
Patients with COVID-19: in the dark-NETs of neutrophils.
新型能量优化剂，美替洛尔，通过靶向磷酸甘油酸激酶 1 快速修复急性低压缺氧诱导的脑损伤。
Cell Commun Signal. 2024 Jul 29;22(1):383. doi: 10.1186/s12964-024-01757-w.
COVID-19 患者：中性粒细胞的黑暗网络。
Cell Death Differ. 2021 Nov;28(11):3125-3139. doi: 10.1038/s41418-021-00805-z. Epub 2021 May 24.
4
Hypoxia-inducible factors not only regulate but also are myeloid-cell treatment targets.缺氧诱导因子不仅起调节作用，也是髓系细胞的治疗靶点。
J Leukoc Biol. 2021 Jul;110(1):61-75. doi: 10.1002/JLB.4RI0820-535R. Epub 2020 Oct 18.
5
HIF1α and metabolic reprogramming in inflammation.炎症中的缺氧诱导因子1α（HIF1α）与代谢重编程
J Clin Invest. 2016 Oct 3;126(10):3699-3707. doi: 10.1172/JCI84431. Epub 2016 Aug 29.
6
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease.富含氧化线粒体DNA的中性粒细胞胞外陷阱具有干扰性，并导致狼疮样疾病。
Nat Med. 2016 Feb;22(2):146-53. doi: 10.1038/nm.4027. Epub 2016 Jan 18.
7
Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation.迁移中性粒细胞通过局部耗氧来塑造黏膜微环境，从而影响炎症的消退。
Immunity. 2014 Jan 16;40(1):66-77. doi: 10.1016/j.immuni.2013.11.020. Epub 2014 Jan 9.
8
Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation.在缺乏超复合物组织的情况下，人中性粒细胞中的线粒体膜电位由复合物III的活性维持。
PLoS One. 2008 Apr 23;3(4):e2013. doi: 10.1371/journal.pone.0002013.
9
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity.缺氧诱导的中性粒细胞存活由HIF-1α依赖性NF-κB活性介导。
J Exp Med. 2005 Jan 3;201(1):105-15. doi: 10.1084/jem.20040624.
10
Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis.中性粒细胞中线粒体的功能特性：仅限于凋亡的作用。
Cell Death Differ. 2004 Feb;11(2):143-53. doi: 10.1038/sj.cdd.4401320.