Coope J, Williams S, Patterson J S
Br J Obstet Gynaecol. 1978 Jun;85(6):472-5. doi: 10.1111/j.1471-0528.1978.tb14916.x.
A prospective, double-blind, randomized comparison of propranolol, 40 mg three times daily, and matching placebo showed propranolol to be no more effective than placebo in controlling hot flushes in a group of 25 perimenopausal women. Other menopausal symptoms, such as insomnia and palpitations, were equally unaffected. However, a very close correlation was found between the daily atmospheric temperature and the number of flushes occurring in the group.
一项前瞻性、双盲、随机对照研究，比较了每日三次服用40毫克普萘洛尔与匹配的安慰剂，结果显示，在一组25名围绝经期妇女中，普萘洛尔在控制潮热方面并不比安慰剂更有效。其他更年期症状，如失眠和心悸，同样未受影响。然而，研究发现每日大气温度与该组出现的潮热次数之间存在非常密切的相关性。
