Schweitzer I, Maguire K P, Gee A H, Tiller J W, Biddle N, Davies B
Department of Psychistry, University of Melbourne, Victoria, Australia.
Br J Psychiatry. 1987 Dec;151:780-4. doi: 10.1192/bjp.151.6.780.
Forty-three depressed patients in hospital were studied with weekly dexamethasone suppression tests (DSTs) and were followed as out-patients for at least three months after discharge. The detection rate of patients with LHPA axis dysfunction increased from 41% with a single DST to 59% with serial DSTs. There was a poor correlation between weekly post-dexamethasone cortisol levels and Hamilton depression rating scores. In patients with evidence of LHPA axis dysfunction, a DST at discharge discriminated effectively between a good and a poor outcome group; persistent non-suppression was strongly linked with a relapse of depression in the first three months after discharge. In general, our results support previous claims that the DST is a state marker for depressive illness.
对43名住院抑郁症患者进行了每周一次的地塞米松抑制试验（DST），并在出院后作为门诊患者随访至少三个月。下丘脑-垂体-肾上腺（LHPA）轴功能障碍患者的检出率从单次DST的41%增至连续DST的59%。地塞米松给药后每周的皮质醇水平与汉密尔顿抑郁评定量表评分之间相关性较差。在有LHPA轴功能障碍证据的患者中，出院时的DST能有效区分预后良好和不良的两组；持续不抑制与出院后前三个月抑郁症复发密切相关。总体而言，我们的结果支持先前的观点，即DST是抑郁症的一种状态标志物。
