Huang Min, Xiao Xiaoxiao, Ji Guanxu, Wu Qiang
The State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao SAR, China.
Heliyon. 2021 Dec 23;8(1):e08664. doi: 10.1016/j.heliyon.2021.e08664. eCollection 2022 Jan.
Post-translational modifications of histone proteins regulate a long cascade of downstream cellular activities, including transcription and replication. Cellular lineage differentiation involves large-scale intracellular signaling and extracellular context. In particular, histone modifications play instructive and programmatic roles in central nervous system development. Deciphering functions of histone could offer feasible molecular strategies for neural diseases caused by histone modifications. Here, we review recent advances of and studies on histone modifications in neural differentiation.
组蛋白的翻译后修饰调控着一系列下游细胞活动，包括转录和复制。细胞谱系分化涉及大规模的细胞内信号传导和细胞外环境。特别是，组蛋白修饰在中枢神经系统发育中发挥着指导和程序性作用。解读组蛋白的功能可为由组蛋白修饰引起的神经疾病提供可行的分子策略。在此，我们综述了关于神经分化中组蛋白修饰的[具体研究内容1]和[具体研究内容2]研究的最新进展。
