Department of Preventive Medicine & Institute of Health Services Research, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Institute of Health Services Research, Yonsei University, Seoul, Republic of Korea.
BMC Psychiatry. 2022 Jan 14;22(1):39. doi: 10.1186/s12888-022-03689-6.
Social phobia shares symptoms with arrhythmias, such as palpitations and chest discomfort. However, it is unclear how social phobia is associated with the actual risk of arrhythmia. This study aimed to investigate whether social phobia is associated with the risk of arrhythmia using a nationally representative sample cohort.
This retrospective cohort study assessed data from the 2002-2013 Korean National Health Insurance Service National Sample Cohort. Using 1:3 propensity score matching for sex, age, income, and insurance status, 1514 patients with social phobia and 4542 control group patients were included in the study. Social phobia and arrhythmia were defined per the International Classification of Diseases, 10th revision. Using cox proportional hazard regression, hazard ratios (HRs) were calculated to estimate the risk of arrhythmia in patients with social phobia.
There were statistically significant associations between social phobia history and elevated risks of arrhythmia. Patients with social phobia had a higher risk of arrhythmia after adjusting with covariates (HR = 1.78, 95%CI = 1.25-2.55). Among different types of arrhythmias, atrial fibrillation and flutter presented the highest risk (HR = 2.20, CI = 1.06-4.57) compared to paroxysmal tachycardia (HR = 1.07, CI = 0.39-2.91) and other cardiac arrhythmias (HR = 1.83, CI = 1.16-2.89).
This study identified the association between social phobia and the risk of arrhythmia in a South Korean representative cohort. These results suggest that social phobia should be treated properly to reduce arrhythmia risks.
社交恐惧症与心律失常有共同的症状，如心悸和胸部不适。然而，社交恐惧症与心律失常的实际风险之间的关系尚不清楚。本研究旨在通过一个具有代表性的全国性样本队列，调查社交恐惧症是否与心律失常的风险相关。
本回顾性队列研究评估了 2002 年至 2013 年韩国国家健康保险服务国家样本队列的数据。通过性别、年龄、收入和保险状况的 1:3 倾向评分匹配，纳入了 1514 例社交恐惧症患者和 4542 例对照组患者。社交恐惧症和心律失常根据国际疾病分类第 10 版定义。使用 cox 比例风险回归，计算风险比（HR）来估计社交恐惧症患者发生心律失常的风险。
社交恐惧症病史与心律失常风险升高有统计学显著关联。调整协变量后，社交恐惧症患者发生心律失常的风险更高（HR=1.78，95%CI=1.25-2.55）。在不同类型的心律失常中，与阵发性心动过速（HR=1.07，95%CI=0.39-2.91）和其他心律失常（HR=1.83，95%CI=1.16-2.89）相比，心房颤动和扑动的风险最高（HR=2.20，95%CI=1.06-4.57）。
本研究在韩国代表性队列中确定了社交恐惧症与心律失常风险之间的关联。这些结果表明，应适当治疗社交恐惧症，以降低心律失常的风险。
