Department of Ophthalmology, University of Nairobi, Nairobi, Kenya.
Ophthalmic Services Unit, Ministry of Health, Nairobi, Kenya.
Ophthalmic Epidemiol. 2023 Dec;30(6):591-598. doi: 10.1080/09286586.2021.1986549. Epub 2022 Jan 17.
Late-stage blinding sequalae of trachoma such as trachomatous trichiasis (TT) typically take decades to develop and often do so in the absence of ongoing ocular infection. This suggests that most TT risk accumulates in early life; as a result, population-level TT incidence and prevalence can remain high years after transmission among children has decreased. In Embu and Kitui counties, Kenya, the prevalence of trachomatous inflammation - follicular is low in children. In this survey, we set out to determine the prevalence of TT in ten evaluation units (EUs) in these counties.
We undertook ten cross-sectional prevalence surveys for TT. In each EU, people aged ≥15 years were selected by a two-stage cluster sampling method and examined for TT. Those with TT were asked questions on whether they had been offered management for it. Prevalence was adjusted to the underlying age and gender structure of the population.
A total of 18,987 people aged ≥15 years were examined. Per EU, the median number of examined participants was 1,656 (range: 1,451 - 3,016) and median response rate was 86% (range: 81 - 95%). The prevalence of TT unknown to the health system in people aged ≥15 years was above the threshold for elimination (≥0.2%) in all ten EUs studied (range: 0.2-0.7%). TT was significantly more common in older than younger individuals and in women than in men.
Provision of surgical services should be strengthened in Embu and Kitui counties of Kenya to achieve the World Health Organization threshold for eliminating TT as a public health problem.
沙眼晚期致盲后遗症,如沙眼性倒睫(TT),通常需要数十年的时间才会发展形成,而且往往是在没有持续眼部感染的情况下发生。这表明 TT 的大部分风险是在生命早期积累的;因此,即使儿童之间的传播减少,多年后,人群中 TT 的发病率和患病率仍可能居高不下。在肯尼亚的埃姆布和基图伊县,儿童中沙眼滤泡性炎症的患病率较低。在这项调查中,我们着手确定该县 10 个评估单位(EU)的 TT 患病率。
我们进行了十项 TT 横断面患病率调查。在每个 EU 中,采用两阶段聚类抽样法选择年龄≥15 岁的人群,并对 TT 进行检查。对于 TT 患者,我们询问他们是否接受过治疗。患病率根据人群的基础年龄和性别结构进行调整。
共有 18987 名年龄≥15 岁的人接受了检查。每个 EU 检查的参与者中位数为 1656 人(范围:1451-3016),中位数的应答率为 86%(范围:81-95%)。在所有研究的 10 个 EU 中,卫生系统未知的≥15 岁人群 TT 患病率均高于消除阈值(≥0.2%)(范围:0.2-0.7%)。TT 在年龄较大的人群中比年龄较小的人群更常见,在女性中比在男性中更常见。
应在肯尼亚的埃姆布和基图伊县加强手术服务的提供,以达到世界卫生组织消除 TT 作为公共卫生问题的阈值。