Sarfraz Zouina, Sarfraz Azza, Sarfraz Muzna, Felix Miguel, Bernstein Jonathan A, Fonacier Luz, Cherrez-Ojeda Ivan
Fatima Jinnah Medical University, Lahore, Pakistan.
The Aga Khan University, Karachi, Pakistan.
Ann Med Surg (Lond). 2022 Feb;74:103254. doi: 10.1016/j.amsu.2022.103254. Epub 2022 Jan 13.
Prolonged use of personal protective equipment (PPE) may lead to contact dermatitis during the coronavirus disease 19 (COVID-19) pandemic. This paper aims to identify the causative factors of contact dermatitis from PPE and hygiene practices.
The search was conducted adhering to PRISMA 2020 guidelines. A Delphi process was employed to ensure that the aims of this study were met. PubMed and Web of Science databases were systematically searched through September 12, 2021, using search terms: Contact dermatitis, case report, covid-19. The findings were tabulated as author/year, gender, age, presentation, cause, dermatological diagnosis, testing modality, provided treatment, symptom resolution (time in days), prognosis, and follow-up.
The mean age of all individuals was 29.75 years, with 75% females. All cases presented with erythema, with 62.5% reporting pruritus and 37.5% reporting burning facial symptoms. Surgical masks and hand-hygiene products (37.5%) were the most commonly reported causative agent with 25% due to KN95/FFP type 2 use. Allergic contact dermatitis (50%) and irritant contact dermatitis (25%) were common diagnoses. Treatments included creams, emollients, and desloratadine, with restriction of irritant-causing factors. The prognosis was generally good among the cases, with 62.5% presenting complete resolution within a week and 12.5% showing moderate improvement at the fourth month after discontinuing use.
This study finds pertinent links between PPE use and contact dermatitis during the COVID-19 pandemic. While many cases are bound to go underreported in literature, well-designed, large-scale studies in the future may help promote these associations in a more comprehensive manner.
在冠状病毒病19（COVID-19）大流行期间，长时间使用个人防护装备（PPE）可能导致接触性皮炎。本文旨在确定PPE和卫生习惯导致接触性皮炎的致病因素。
检索遵循PRISMA 2020指南进行。采用德尔菲法以确保本研究的目标得以实现。截至2021年9月12日，系统检索了PubMed和Web of Science数据库，使用的检索词为：接触性皮炎、病例报告、covid-19。研究结果按作者/年份、性别、年龄、表现、病因、皮肤病学诊断、检测方式、提供的治疗、症状缓解（天数）、预后和随访进行列表。
所有个体的平均年龄为29.75岁，女性占75%。所有病例均出现红斑，62.5%报告有瘙痒，37.5%报告有面部灼烧症状。外科口罩和手部卫生用品（37.5%）是最常报告的致病因素，25%是由于使用KN95/FFP 2型口罩。变应性接触性皮炎（50%）和刺激性接触性皮炎（25%）是常见诊断。治疗包括乳膏、润肤剂和地氯雷他定，并限制引起刺激的因素。这些病例的预后总体良好，62.5%在一周内完全缓解，12.5%在停止使用后的第四个月有中度改善。
本研究发现了COVID-19大流行期间PPE使用与接触性皮炎之间的相关联系。虽然文献中许多病例可能未被报告，但未来精心设计的大规模研究可能有助于更全面地揭示这些关联。
