Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Haidian District, Beijing 100193, People's Republic of China.
Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences & Peking Union Medical College, Haikou 570311, People's Republic of China.
J Nat Prod. 2022 Jan 28;85(1):127-135. doi: 10.1021/acs.jnatprod.1c00849. Epub 2022 Jan 18.
Eight new cadinane sesquiterpenoids (-), along with two known compounds ( and ), were isolated from infected stems of the semi-mangrove plant, . The structures of compounds - were elucidated through the analysis of their 1D and 2D NMR and MS data, and their absolute configurations were determined by comparing their experimental and calculated ECD spectra and by single-crystal X-ray diffraction. The two confused known compounds ( and ) were resolved using single-crystal X-ray crystallography. Compounds - have novel norsesquiterpene carbon skeletons arising from a ring contraction rearrangement. All obtained isolates were evaluated against the HepG2 and Huh7 cell lines, and compounds , , , , and showed cytotoxic activity toward both cell lines, with IC values ranging from 3.5 to 6.8 μM.
从半红树林植物 感染的茎中分离得到了 8 种新的卡丹烷倍半萜（-），以及两种已知化合物（和）。通过分析它们的 1D 和 2D NMR 和 MS 数据，阐明了化合物 - 的结构，并通过比较它们的实验和计算 ECD 光谱以及单晶 X 射线衍射确定了它们的绝对构型。使用单晶 X 射线晶体学解析了两种混淆的已知化合物（和）。化合物 - 具有新颖的诺尔斯奎萜烯碳骨架，源自环收缩重排。所有获得的分离物都针对 HepG2 和 Huh7 细胞系进行了评估，化合物 、 、 、 、 对这两个细胞系均表现出细胞毒性活性，IC 值范围为 3.5 至 6.8 μM。
