具有细胞毒性和抗菌活性的真菌倍半萜类化合物。
Sesquiterpenes from the Fungus with Cytotoxicity and Antibacterial Activity.
作者信息
Ning Jinlei, Wu Feng, Liu Jikai, He Juan, Feng Tao
机构信息
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
出版信息
J Fungi (Basel). 2023 Apr 28;9(5):521. doi: 10.3390/jof9050521.
Eight new sesquiterpenes, namely, albocinnamins A-H (-), along with two known ones ( and ), have been isolated from the fungus . Compound possesses a new backbone that might be derived from cadinane-type sesquiterpene. Structures of the new compounds were elucidated by detailed spectroscopic data analysis, single-crystal X-ray diffraction, and ECD calculations. Compounds and showed cytotoxicity against SW480 and MCF-7 cells, with IC values ranging from 19.3 to 33.3 μM, while compound displayed cytotoxicity against the HL-60 cell with an IC value of 12.3 μM. In addition, compounds and exhibited antibacterial activity against with MIC values of 64 and 64 µg/mL, respectively.
从该真菌中分离出了8种新的倍半萜，即白肉桂素A - H（-），以及两种已知的倍半萜（和）。化合物具有一种可能源自杜松烷型倍半萜的新骨架。通过详细的光谱数据分析、单晶X射线衍射和ECD计算阐明了新化合物的结构。化合物和对SW480和MCF - 7细胞显示出细胞毒性，IC值范围为19.3至33.3 μM，而化合物对HL - 60细胞显示出细胞毒性，IC值为12.3 μM。此外，化合物和对表现出抗菌活性，MIC值分别为64和64 μg/mL。
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