Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea.
Neurosci Lett. 2022 Feb 16;772:136451. doi: 10.1016/j.neulet.2022.136451. Epub 2022 Jan 15.
The effect of gaming cue exposure on brain activity in patients with internet gaming disorder (IGD) has been investigated a lot, but the effect on brain connectivity has not. This study aimed to investigate the effects of imageries of gaming and alternative leisure activities on functional connectivity during the during-task and post-task states in patients with IGD.
Twenty-nine patients and 20 healthy controls were scanned in the 6-min states before, during, and after the imagery tasks for gaming and alternative leisure behaviors using fMRI. Seed-based functional connectivity during and after the tasks were analyzed. The seeds were the nucleus accumbens (NAcc), ventral tegmental area (VTA), caudate, putamen, anterior cingulate cortex (ACC), and posterior cingulate cortex.
The group-by-state interaction effects for the during-tasks were found in caudate-, putamen-, and ACC-based connectivity, whereas those for the post-tasks were shown only in NAcc-based connectivity. In particular, patients showed that caudate-right parahippocampal gyrus connectivity and putamen-right orbitofrontal cortex connectivity increased during gaming and decreased during alternative, whereas NAcc-right precuneus connectivity decreased at baseline, increased in post-gaming, and were not different in post-alternative.
Differences in during-task connectivity of the habit/motor and salience networks and post-task resting-state connectivity of the reward and limbic networks between the two imagery tasks may differ between the groups. In the treatment of IGD, when these network connections are reactive to alternative leisure activity, just as to gaming activity, they seem to be freed from gaming addiction.
已有大量研究调查了游戏线索暴露对网络成瘾障碍（IGD）患者大脑活动的影响，但对大脑连接的影响尚未研究。本研究旨在调查在想象游戏和替代休闲活动期间和之后，IGD 患者的大脑功能连接的变化。
29 名患者和 20 名健康对照组在想象游戏和替代休闲行为的 6 分钟任务前、任务中和任务后使用 fMRI 进行扫描。分析了任务期间和之后的基于种子的功能连接。种子为伏隔核（NAcc）、腹侧被盖区（VTA）、尾状核、壳核、前扣带回皮质（ACC）和后扣带回皮质。
在任务期间，患者组与状态的交互作用影响了基于尾状核、壳核和 ACC 的连接，而在任务后，只有基于 NAcc 的连接才显示出这种影响。特别是，患者在想象游戏时表现出右侧海马旁回和右侧眶额皮质的尾状核连接增加，而在想象替代活动时减少，而 NAcc 与右侧顶下小叶的连接在基线时减少，在想象游戏后增加，而在想象替代后无差异。
在这两种想象任务中，习惯/运动网络和突显网络的任务期间连接和奖赏与边缘网络的任务后静息状态连接的差异可能在两组之间有所不同。在治疗 IGD 时，如果这些网络连接对替代休闲活动的反应与对游戏活动的反应一样，那么它们似乎可以摆脱游戏成瘾。
