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基于 T 细胞和自然杀伤细胞的免疫疗法在慢性病毒性肝炎和肝细胞癌中的应用。

T and NK Cell-Based Immunotherapy in Chronic Viral Hepatitis and Hepatocellular Carcinoma.

机构信息

Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, 43126 Parma, Italy.

Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.

出版信息

Cells. 2022 Jan 6;11(2):180. doi: 10.3390/cells11020180.

DOI:10.3390/cells11020180
PMID:35053296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8773863/
Abstract

In chronic viral hepatitis and in hepatocarcinoma (HCC), antigen-specific T cells are deeply exhausted, and evidence of dysfunction has also been observed for NK cells, which can play a pathogenetic role, exerting a regulatory activity on adaptive immune responses [...].

摘要

在慢性病毒性肝炎和肝癌（HCC）中，抗原特异性 T 细胞深度耗竭，NK 细胞也出现功能障碍的证据，NK 细胞可发挥致病作用，对适应性免疫反应发挥调节作用[... ]。

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Cells. 2021 Jul 22;10(8):1861. doi: 10.3390/cells10081861.
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