Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China.
Clinical Research Center for Medical Imaging in Hubei Province, 430022, Wuhan, China.
Lipids Health Dis. 2022 Jan 22;21(1):14. doi: 10.1186/s12944-022-01625-x.
Calcific aortic valve disease (CAVD) has a substantial and increasing burden in the ageing population with occult onset.Present study aimed to assess association of clinical characteristics of these patients and occurrence of CAVD.
Patients diagnosed with CAVD and those receiving healthy medical examination in our hospital from January 2019 to February 2021 were enrolled in this retrospective study. Clinical characteristics, ultrasonic indicators, serological indicators and histology of CAVD were collected and compared among different groups. Logistic regression and Pearson correlation analysis was used to explore relationship between these indexes and occurrence of CAVD.
DBP, SBP, LVESD, LVEDD, IVS, PW, AV Vmax, TC, TG, LDL-C, Fetuin-A, Lp(a) in severe group were higher than mild, moderate and control groups (P<0.05), while those indexes of patients in moderate group were higher than that in mild and controlled groups (P<0.05). Besides, theses indexes of patients in mild group were also higher than that of controlled one (P<0.05). However, LVEF, HDL-C and MGP of patients in severe group was the lowest (P<0.05), while those in moderate group were lower than mild and controlled groups. Moreover, these indexes in mild group were also lower than control group (P<0.05). In Logistic regression analysis, MGP, Fetuin-A and Lp(a) were all independently associated with occurrence of CAVD (P<0.05). In Pearson correlation analysis, Fetuin-A and Lp(a) were positively correlated with progression of the disease, while MGP and macrophage density were negatively correlated with it.
Fetuin-A, MPG and Lp(a) were independently associated with the occurrence of CAVD, and they might be potential predictors for diagnosis of this disease.
在老龄化人口中，隐匿性起病的钙化性主动脉瓣疾病（CAVD）具有较大且不断增加的负担。本研究旨在评估这些患者的临床特征与 CAVD 发生之间的关系。
本回顾性研究纳入了 2019 年 1 月至 2021 年 2 月期间在我院诊断为 CAVD 的患者和接受健康体检的患者。收集并比较了不同组间患者的临床特征、超声指标、血清学指标和 CAVD 组织学。采用 logistic 回归和 Pearson 相关性分析探讨这些指标与 CAVD 发生之间的关系。
重度组的 DBP、SBP、LVESD、LVEDD、IVS、PW、AV Vmax、TC、TG、LDL-C、Fetuin-A、Lp(a)高于轻度、中度和对照组（P<0.05），而中度组患者的这些指标高于轻度和对照组（P<0.05）。此外，轻度组患者的这些指标也高于对照组（P<0.05）。然而，重度组患者的 LVEF、HDL-C 和 MGP 最低（P<0.05），中度组低于轻度和对照组，轻度组也低于对照组（P<0.05）。在 logistic 回归分析中，MGP、Fetuin-A 和 Lp(a)均与 CAVD 的发生独立相关（P<0.05）。在 Pearson 相关性分析中，Fetuin-A 和 Lp(a)与疾病进展呈正相关，而 MGP 和巨噬细胞密度与疾病进展呈负相关。
Fetuin-A、MPG 和 Lp(a)与 CAVD 的发生独立相关，它们可能是该疾病诊断的潜在预测指标。
