Departamento de Quimica, Instituto de Ciencias Exatas, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
Curr Pharm Des. 2021;27(15):1763-1789. doi: 10.2174/1381612826666201113104633.
Trypanosomatid parasites are responsible for many Neglected Tropical Diseases (NTDs). NTDs are a group of illnesses that prevail in low-income populations, such as in tropical and subtropical areas of Africa, Asia, and the Americas. The three major human diseases caused by trypanosomatids are African trypanosomiasis, Chagas disease and leishmaniasis. There are known drugs for the treatment of these diseases that are used extensively and are affordable; however, the use of these medicines is limited by several drawbacks such as the development of chemo-resistance, side effects such as cardiotoxicity, low selectivity, and others. Therefore, there is a need to develop new chemotherapeutic against these tropical parasitic diseases. Metal-based drugs against NTDs have been discussed over the years as alternative ways to overcome the difficulties presented by approved antiparasitic agents. The study of late transition metal-based drugs as chemotherapeutics is an exciting research field in chemistry, biology, and medicine due to the ability to develop multitarget antiparasitic agents. The evaluation of the late transition metal complexes for the treatment of trypanosomatid diseases is provided here, as well as some insights about their mechanism of action.
锥虫生物是许多被忽视的热带病（NTDs）的罪魁祸首。NTDs 是一组在低收入人群中流行的疾病，如非洲、亚洲和美洲的热带和亚热带地区。由锥虫引起的三种主要人类疾病是非洲锥虫病、恰加斯病和利什曼病。目前已有针对这些疾病的治疗药物广泛使用且价格实惠；然而，这些药物的使用受到多种因素的限制，如抗药性的发展、心脏毒性等副作用、选择性低等。因此，需要开发针对这些热带寄生虫病的新化疗药物。多年来，金属基药物已被讨论为克服已批准的抗寄生虫药物所带来的困难的替代方法。由于能够开发多靶点抗寄生虫药物，研究后期过渡金属基药物作为化疗药物是化学、生物学和医学领域令人兴奋的研究领域。本文提供了针对锥虫疾病治疗的后期过渡金属配合物的评估，以及关于其作用机制的一些见解。
