College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture and Rural Affairs, Key Laboratory of Agro-Products Postharvest Handling of Ministry of Agriculture and Rural Affairs, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang International Scientific and Technological Cooperation Base of Health Food Manufacturing and Quality Control, Zhejiang University, Hangzhou 310058, China.
Fuli Institute of Food Science, Zhejiang University, Hangzhou 310058, China.
J Agric Food Chem. 2022 Feb 2;70(4):1148-1162. doi: 10.1021/acs.jafc.1c07583. Epub 2022 Jan 24.
The present study investigated the effects of flowers and acteoside on murine colitis and the underlying mechanisms. The flower extract (OFE) and acteoside were administrated to chemically induced colitic mice. The results showed that OFE or acteoside ameliorates intestinal inflammation, oxidative stress, and activation of nuclear factor-κB (NF-κB) in colitic mice. The dysbiosis of the gut microbiome in colitic mice was also partly restored by OFE or acteoside, which was characterized by the alteration of the gut microbiome structure and the enrichment of beneficial bacteria ( and ). Dextran sulfate sodium (DSS)-induced gut metabolome dysfunctions (e.g., sphingosine metabolism and amino acids metabolism) in colitic mice were also partly restored by OFE and acteoside. A fecal microbiota (FM) transplantation study suggested that, compared with the FM from the normal diet-dosed donor mice, the FM from the OFE- or acteoside-dosed donor mice significantly suppressed colitic symptoms.
本研究探讨了花和獐牙菜苷对小鼠结肠炎的作用及其机制。将花提取物（OFE）和獐牙菜苷给予化学诱导的结肠炎小鼠。结果表明，OFE 或獐牙菜苷可改善结肠炎小鼠的肠道炎症、氧化应激和核因子-κB（NF-κB）的激活。OFE 或獐牙菜苷还部分恢复了结肠炎小鼠肠道微生物组的失调，其特征为肠道微生物组结构的改变和有益细菌（和）的富集。OFE 和獐牙菜苷还部分恢复了葡聚糖硫酸钠（DSS）诱导的结肠炎小鼠肠道代谢组功能障碍（例如，鞘氨醇代谢和氨基酸代谢）。粪便微生物组（FM）移植研究表明，与来自正常饮食剂量供体小鼠的 FM 相比，来自 OFE 或獐牙菜苷剂量供体小鼠的 FM 显著抑制了结肠炎症状。
