Moon Hye-Jung, Cha Youn-Soo, Kim Kyung-Ah
Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju, Republic of Korea.
K-Food Research Center, Jeonju, Republic of Korea.
Food Nutr Res. 2025 Jul 21;69. doi: 10.29219/fnr.v69.11052. eCollection 2025.
(Miseon tree), a native Korean plant, is known for the high phenolic content in its leaves. The ethanolic leaf extracts of have shown antioxidant, anti-obesity, and anti-inflammatory properties. However, studies on its potential to improve colitis are limited. This study aimed to determine whether the ethanolic extract of leaves (ADE) could alleviate dextran sulfate sodium (DSS)-induced colitis in mice. The mice were divided into three groups, and the experimental group was given 300 mg/kg ADE for 4 weeks. One week before the end of the experiment, 3% DSS was added to the drinking water to induce colitis. The clinical symptoms of colitis and damage to colon tissue, including the increase in abundance and a decrease in in the colon, were evaluated during DSS treatment. DSS overactivated the nuclear factor (NF)-κB signaling pathway, resulting in excessive production of pro-inflammatory cytokines. In contrast, ADE alleviated the DSS-induced colitis symptoms, protected against colonic tissue damage, and restored the balance of and levels in the colon. Moreover, ADE effectively inhibited the DSS-induced overactivation of the NF-κB signaling pathway within the colon and mitigated abnormal inflammatory responses. These findings suggest that ADE protects against colitis by modulating the growth of some intestinal strains and the NF-κB pathway in the colon, supporting its potential as a natural agent.
米森树是一种韩国本土植物，以其叶片中高含量的酚类物质而闻名。其乙醇叶提取物已显示出抗氧化、抗肥胖和抗炎特性。然而，关于其改善结肠炎潜力的研究有限。本研究旨在确定米森树叶乙醇提取物（ADE）是否能减轻葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎。将小鼠分为三组，实验组给予300mg/kg ADE，持续4周。在实验结束前一周，向饮用水中添加3% DSS以诱导结肠炎。在DSS治疗期间评估结肠炎的临床症状和结肠组织损伤，包括结肠中 丰度的增加和 含量的降低。DSS过度激活核因子（NF）-κB信号通路，导致促炎细胞因子过度产生。相比之下，ADE减轻了DSS诱导的结肠炎症状，保护结肠组织免受损伤，并恢复了结肠中 和 水平的平衡。此外，ADE有效抑制了结肠内DSS诱导的NF-κB信号通路过度激活，并减轻了异常炎症反应。这些发现表明，ADE通过调节结肠中某些肠道菌株的生长和NF-κB途径来预防结肠炎，支持其作为天然药物的潜力。
