Department Cell, Developmental, and Regenerative Biology Icahn School of Medicine at Mount Sinai One Gustave L. Levy Place, New York, United States.
Elife. 2022 Jan 25;11:e76106. doi: 10.7554/eLife.76106.
Fertility in female mammals, including mice and humans, is dependent on the presence of a zona pellucida (ZP) around growing oocytes and unfertilized eggs. A ZP is required to stabilize contacts between oocyte microvilli and follicle cell projections that traverse the ZP to form gap junctions that support the health of growing oocytes and developing follicles. In the absence of a ZP, due to inactivation or mutation of genes encoding ZP proteins, there is a loss of contacts between growing oocytes and neighboring follicle cells and a concomitant reduction in the production of ovulated eggs that results in female infertility.
哺乳动物的生育能力，包括老鼠和人类，依赖于生长中的卵母细胞和未受精卵周围的透明带（ZP）的存在。ZP 对于稳定卵母细胞微绒毛和穿过 ZP 形成间隙连接的卵泡细胞突起之间的接触是必需的，间隙连接支持生长中的卵母细胞和发育中的卵泡的健康。在没有 ZP 的情况下，由于编码 ZP 蛋白的基因失活或突变，生长中的卵母细胞与相邻的卵泡细胞之间的接触丧失，并且同时减少了排卵卵子的产生，导致女性不育。
