Afzal Zainab, Krumlauf Robb
Stowers Institute for Medical Research, 1000 E. 50th, Kansas City, MO 64110, USA.
Department of Anatomy and Cell Biology, Kansas University Medical Center, Kansas City, MO 66160, USA.
J Dev Biol. 2022 Jan 10;10(1):4. doi: 10.3390/jdb10010004.
genes play key roles in axial patterning and regulating the regional identity of cells and tissues in a wide variety of animals from invertebrates to vertebrates. Nested domains of expression generate a combinatorial code that provides a molecular framework for specifying the properties of tissues along the A-P axis. Hence, it is important to understand the regulatory mechanisms that coordinately control the precise patterns of the transcription of clustered genes required for their roles in development. New insights are emerging about the dynamics and molecular mechanisms governing transcriptional regulation, and there is interest in understanding how these may play a role in contributing to the regulation of the expression of the clustered genes. In this review, we summarize some of the recent findings, ideas and emerging mechanisms underlying the regulation of transcription in general and consider how they may be relevant to understanding the transcriptional regulation of genes.
基因在从无脊椎动物到脊椎动物的多种动物的轴模式形成以及调控细胞和组织的区域特性方面发挥着关键作用。嵌套的表达结构域产生一种组合密码，为沿前后轴指定组织特性提供分子框架。因此，了解协调控制其在发育中发挥作用所需的成簇基因转录精确模式的调控机制非常重要。关于转录调控的动力学和分子机制正在出现新的见解，人们有兴趣了解这些机制如何在成簇基因表达调控中发挥作用。在本综述中，我们总结了一些关于转录调控的最新发现、观点和新兴机制，并考虑它们如何与理解基因的转录调控相关。
