Hu F, Mah K, Teramura D J
Oregon Regional Primate Research Center, Beaverton 97006.
Pigment Cell Res. 1987;1(2):104-10. doi: 10.1111/j.1600-0749.1987.tb00397.x.
Theophylline enhances maturation and differentiation of uveal melanocytes. By electron microscopy, we showed that theophylline changes small, dendritic melanocytes into large, platelike cells; it also enhances DOPA reaction as evidenced by increased deposition of DOPA reaction products in dilated cisternae and vesicles around the Golgi region. The effect is partially reversible in choroidal melanocytes but irreversible in iridial cells. It appears that theophylline, in addition to inducing tyrosine activity, accelerates the maturation and/or aging that normally occurs in cultured melanocytes when incubation is prolonged.
茶碱可促进葡萄膜黑色素细胞的成熟和分化。通过电子显微镜观察，我们发现茶碱可使小的树突状黑色素细胞转变为大的扁平状细胞；它还增强了多巴反应，这表现为高尔基体区域周围扩张的池和小泡中多巴反应产物沉积增加。这种作用在脉络膜黑色素细胞中部分可逆，但在虹膜细胞中不可逆。看来，茶碱除了诱导酪氨酸活性外，还加速了培养的黑色素细胞在延长孵育时间时正常发生的成熟和/或老化过程。
