Mosimann F, Mirkovitch V, Macarone-Palmieri R, Blanc D, Campiche M
Helv Chir Acta. 1978 May;45(1-2):157-9.
Two groups of mongrel dogs underwent intrasplenic autotransplantation of pancreatic tissues prepared from the head and tail of the organ. In the first group (12), the operation was terminated by the removal of the rest of the gland. In the second group (8), total pancreatectomy was done 6-8 months after autotransplantation. The first group of dogs became spontaneously normoglycemic after ten days of moderate hyperglycemia; their insulinemia increased significantly during a glucose loading test. The second group of dogs never became normoglycemic but remained vivacious; insulin level in their splenic vein increased moderately only after glucose injection. Microscopically, exo- and endocrine pancreatic tissues were seen in the spleens of the first group of dogs; in the spleens of the second group of dogs, only a few degenerating B cells were observed. These results suggest that the temporary hyperglycemia following autotransplantation of pancreatic tissues is a functional demand: it is necessary for ultimate survival and function of transplanted B cells.
两组杂种狗接受了取自胰腺头部和尾部的胰腺组织的脾内自体移植。在第一组（12只）中，手术通过切除腺体的其余部分而结束。在第二组（8只）中，自体移植后6 - 8个月进行了全胰切除术。第一组狗在中度高血糖10天后自发地恢复正常血糖水平；在葡萄糖负荷试验期间，它们的胰岛素血症显著增加。第二组狗从未恢复正常血糖水平，但仍很活泼；仅在注射葡萄糖后，它们脾静脉中的胰岛素水平适度增加。显微镜检查显示，第一组狗的脾脏中可见外分泌和内分泌胰腺组织；在第二组狗的脾脏中，仅观察到少数退化的B细胞。这些结果表明，胰腺组织自体移植后短暂的高血糖是一种功能需求：这对于移植的B细胞的最终存活和功能是必要的。
