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“渐强性短暂性脑缺血发作”——一种常见疾病的罕见表现:一例关于丘脑-内囊警告综合征的病例报告

'Crescendo transient ischemic attack'-an uncommon presentation of a very common disease: a case report on capsular warning syndrome.

作者信息

Payus Alvin Oliver, Ibrahim Azliza, Sheaker Vinushini Chandra, Yahya Wan Nur Nafisah Wan

机构信息

Faculty of Medicine and Health Science, Universiti Malaysia Sabah (UMS), Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia.

Department of Neurology, Hospital Pengajar Universiti Putra Malaysia, Persiaran Mardi - UPM, 43400 Serdang, Selangor, Malaysia.

出版信息

Oxf Med Case Reports. 2022 Jan 24;2022(1):omab129. doi: 10.1093/omcr/omab129. eCollection 2022 Jan.

DOI:10.1093/omcr/omab129
PMID:35083048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8787630/
Abstract

Capsular warning syndrome is a rare presentation of transient ischaemic attack, which described as recurrent episodes of motor and/or sensory deficits which typically sparring the cortical function. It has a significant risk to progress into a massive stroke with permanent disability, thus important to be recognise early. Here, we report a middle-age gentleman with no known medical illness presented with eight episodes of transient ischaemic attack within the span of 24 h. He was treated with double anti-platelet for 21 days and was not subjected to thrombolysis at time of presentation because it was outside the window period of 4.5 h, and has fully recovered after each episode. The purpose of this case report is to share the uncommon clinical presentation of transient ischaemic attack, which is still not fully understood and warrant more studies especially on the treatment that can affect the progression of the disease.

摘要

包膜警告综合征是短暂性脑缺血发作的一种罕见表现,其被描述为运动和/或感觉缺陷的反复发作,通常不影响皮质功能。它有进展为导致永久性残疾的大面积中风的重大风险,因此早期识别很重要。在此,我们报告一位无已知病史的中年男性,在24小时内出现了8次短暂性脑缺血发作。他接受了21天的双重抗血小板治疗,就诊时未进行溶栓治疗,因为已超出4.5小时的窗口期,且每次发作后均已完全康复。本病例报告的目的是分享短暂性脑缺血发作这种不常见的临床表现,其仍未被完全理解,需要更多研究,尤其是关于可能影响疾病进展的治疗方法的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634b/8787630/d26862d55a88/omab129f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634b/8787630/d26862d55a88/omab129f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634b/8787630/d26862d55a88/omab129f1.jpg

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本文引用的文献

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Capsular warning syndrome: clinical analysis and treatment.胶囊警告综合征:临床分析与治疗。
BMC Neurol. 2019 Nov 13;19(1):285. doi: 10.1186/s12883-019-1522-0.
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The Importance of Combined Antithrombotic Treatment for Capsular Warning Syndrome.联合抗栓治疗对包膜警告综合征的重要性。
J Stroke Cerebrovasc Dis. 2018 Nov;27(11):3095-3099. doi: 10.1016/j.jstrokecerebrovasdis.2018.06.038. Epub 2018 Aug 2.
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Clinical characteristics and outcome of the capsular warning syndrome: a multicenter study.囊膜预警综合征的临床特征与结局:一项多中心研究
Int J Stroke. 2015 Jun;10(4):571-5. doi: 10.1111/ijs.12432. Epub 2014 Dec 18.
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The capsular warning syndrome: pathogenesis and clinical features.包膜警告综合征:发病机制与临床特征
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