Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, 130000, China.
Department of Gastrointestinal Surgery, The Second Hospital of Jilin University, Changchun, 130000, China.
J Cancer Res Clin Oncol. 2022 Mar;148(3):547-564. doi: 10.1007/s00432-021-03892-0. Epub 2022 Jan 27.
Autophagy and EMT (epithelial-mesenchymal transition) are the two principal biological processes and ideal therapeutic targets during cancer development. Autophagy, a highly conserved process for degrading dysfunctional cellular components, plays a dual role in tumors depending on the tumor stage and tissue types. The EMT process is the transition differentiation from an epithelial cell to a mesenchymal-like cell and acquiring metastatic potential. There is evidence that the crosstalk between autophagy and EMT is complex in cancer. In recent years, more studies have shown that long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are involved in autophagy, EMT, and their crosstalk. Therefore, accurate understanding of the regulatory mechanisms of lncRNAs and miRNAs in autophagy, EMT and their interactions is crucial for the clinical management of cancers.
An extensive literature search was conducted on the Google Scholar and PubMed databases. The keywords used for the search included: autophagy, EMT, crosstalk, lncRNAs, miRNAs, cancers, diagnostic biomarkers, and therapeutic targets. This search provided relevant articles published in peer-reviewed journals until 2021. Data from these various studies were extracted and used in this review.
The results showed that lncRNAs/miRNAs as tumor inhibitors or tumor inducers could regulate autophagy, EMT, and their interaction by regulating several molecular signaling pathways. The lncRNAs/miRNAs involved in autophagy and EMT processes could have potential uses in cancer diagnosis, prognosis, and therapy.
Such information could help find and develop lncRNAs/miRNAs based new tools for diagnosing, prognosis, and creating anti-cancer therapies.
自噬和 EMT（上皮-间质转化）是癌症发展过程中的两个主要生物学过程和理想的治疗靶点。自噬是一种降解功能失调的细胞成分的高度保守过程，在肿瘤中根据肿瘤阶段和组织类型发挥双重作用。EMT 过程是上皮细胞向间充质样细胞的转化，并获得转移潜能。有证据表明，自噬和 EMT 之间的串扰在癌症中是复杂的。近年来，越来越多的研究表明，长非编码 RNA（lncRNA）和 microRNA（miRNA）参与自噬、EMT 及其相互作用。因此，准确理解 lncRNA 和 miRNA 在自噬、EMT 及其相互作用中的调控机制对于癌症的临床管理至关重要。
在 Google Scholar 和 PubMed 数据库上进行了广泛的文献检索。用于搜索的关键词包括：自噬、EMT、串扰、lncRNA、miRNA、癌症、诊断生物标志物和治疗靶点。该搜索提供了截至 2021 年在同行评议期刊上发表的相关文章。从这些不同的研究中提取数据并用于本综述。
结果表明，lncRNA/miRNA 作为肿瘤抑制剂或肿瘤诱导剂，可以通过调节几种分子信号通路来调节自噬、EMT 及其相互作用。参与自噬和 EMT 过程的 lncRNA/miRNA 可能在癌症诊断、预后和治疗中具有潜在用途。
这些信息可以帮助发现和开发基于 lncRNA/miRNA 的新工具，用于诊断、预后和抗癌治疗。
