Chongqing Normal University, Chongqing, China.
PeerJ. 2023 Sep 27;11:e16130. doi: 10.7717/peerj.16130. eCollection 2023.
Gastrointestinal cancer has always been one of the most urgent problems to be solved, and it has become a major global health issue. Microorganisms in the gastrointestinal tract regulate normal physiological and pathological processes. Accumulating evidence reveals the role of the imbalance in the microbial community during tumorigenesis. Autophagy is an important intracellular homeostatic process, where defective proteins and organelles are degraded and recycled under stress. Autophagy plays a dual role in tumors as both tumor suppressor and tumor promoter. Many studies have shown that autophagy plays an important role in response to microbial infection. Here, we provide an overview on the regulation of the autophagy signaling pathway by microorganisms in gastrointestinal cancer.
胃肠道癌症一直是亟待解决的最紧迫问题之一，它已成为一个主要的全球健康问题。胃肠道中的微生物调节着正常的生理和病理过程。越来越多的证据揭示了肿瘤发生过程中微生物群落失衡的作用。自噬是一种重要的细胞内稳态过程，在应激下，缺陷的蛋白质和细胞器被降解和再循环。自噬在肿瘤中起双重作用，既是肿瘤抑制因子又是肿瘤促进因子。许多研究表明，自噬在应对微生物感染中起着重要作用。在这里，我们概述了微生物对胃肠道癌症中自噬信号通路的调节。
