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辅助蛋白变异体在 SARS-CoV-2 致病性中的重要性。

The importance of accessory protein variants in the pathogenicity of SARS-CoV-2.

机构信息

Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram, 721140, India.

Applied Statistics Unit, Indian Statistical Institute, Kolkata, 700108, West Bengal, India.

出版信息

Arch Biochem Biophys. 2022 Mar 15;717:109124. doi: 10.1016/j.abb.2022.109124. Epub 2022 Jan 24.

DOI:10.1016/j.abb.2022.109124
PMID:35085577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8785432/
Abstract

The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2.

摘要

新型冠状病毒病 2019（COVID-19）是由严重急性呼吸系统综合症冠状病毒 2 型（SARS-CoV-2）引起的，估计死亡率低于 1%。SARS-CoV-2 的辅助蛋白 ORF3a、ORF6、ORF7a、ORF7b、ORF8 和 ORF10 具有操纵宿主免疫机制的潜在功能。这些功能涉及干扰素，干扰素似乎是一种共识功能，免疫信号受体 NLRP3（NLR 家族富含吡咯域蛋白 3）炎性小体，以及白细胞介素 1β（IL-1β）等炎症细胞因子，在 COVID-19 病理中至关重要。根据 2020 年 11 月之前报告的数据，在六个大洲的所有完整 SARS-CoV-2 蛋白质组中观察到六种辅助蛋白的扩展变异。确定辅助蛋白中独特变异的百分比递减顺序为 ORF3a>ORF8>ORF7a>ORF6>ORF10>ORF7b，遍及所有大洲。ORF3a 的最高和最低独特变异分别在南美洲和大洋洲观察到。这些发现表明，辅助蛋白的广泛变异似乎影响了 SARS-CoV-2 的致病性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/0b1ebbe6b62b/gr18_lrg.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/fdb0f8bc39c0/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/1006ead6eaa3/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/38c11338acb0/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/86c8981670cf/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/b50473e764bb/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/d8886f6f1db5/gr8_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/755ecb184966/gr9_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/bfe0ab599adf/gr10_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/4823c0e29562/gr11_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/8329eb890541/gr12_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/0277ce367240/gr13_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/bc171b2eb2c8/gr14_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/3cef767edd79/gr15_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/f5425ea9f590/gr16_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/d118679bfcfa/gr17_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/0b1ebbe6b62b/gr18_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/39260127582d/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/3d9ce5f923fc/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/fdb0f8bc39c0/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/1006ead6eaa3/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/38c11338acb0/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/86c8981670cf/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/b50473e764bb/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/d8886f6f1db5/gr8_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/755ecb184966/gr9_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/bfe0ab599adf/gr10_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/4823c0e29562/gr11_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/8329eb890541/gr12_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/0277ce367240/gr13_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/bc171b2eb2c8/gr14_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/3cef767edd79/gr15_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/f5425ea9f590/gr16_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/d118679bfcfa/gr17_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/8785432/0b1ebbe6b62b/gr18_lrg.jpg

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