Cheung Forrest Tin Wai, Ho Amy Wing Yin, Chan Joey Wing Yan, Li Xiao, Chan Ngan Yin, Zhang Jihui, Ho Chung Shun, Wing Yun Kwok, Li Shirley Xin
Sleep Research Clinic and Laboratory, Department of Psychology, The University of Hong Kong, Hong Kong.
Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Chronobiol Int. 2022 May;39(5):678-689. doi: 10.1080/07420528.2022.2025821. Epub 2022 Jan 27.
Chronotype, referred to as an individual's diurnal preference of timing for rest and activity, can be subjectively measured using the Munich Chronotype Questionnaire (MCTQ). However, the validity of MCTQ has yet to be tested in the youth population. In addition, it remains uncertain if MCTQ is a good measure of chronotype in individuals with insomnia. The current study aimed to validate the Chinese version of MCTQ (MCTQ) in the youth population and to explore the utility of MCTQ in individuals with insomnia. The original MCTQ was translated into Chinese language using the translation-back-translation method. Part one of this study included 988 youths who completed a battery of self-report questionnaires online consisting of the MCTQ and the morningness-eveningness questionnaire (MEQ) for the measures of circadian preference, Insomnia Severity Index (ISI) to assess insomnia symptoms, and Patient Health Questionnaire (PHQ-9) to measure depressive symptoms. Test-retest reliability was examined in 442 participants at one-month follow-up. Of the overall sample, 69 participants were randomly drawn to complete the second part of the study, which included prospective 7-day actigraphy monitoring and a further subset (n = 40) additionally completed a laboratory-based assessment of dim-light melatonin onset (DLMO) as a circadian phase marker. A total of 659 participants with valid responses were finally included in the analyses of the data collected from part one of the study (female = 67.7%; mean age: 20.7 ± 2.02). Results showed that MCTQ parameters, namely the midpoint of sleep on free days (MSF), midpoint of sleep on workdays (MSW), and midpoint of sleep adjusted for sleep debt (MSFsc), were significantly correlated with MEQ score (r = -.514 to -.650, < .01). Test-retest reliability for MCTQ was good (intraclass correlation = 0.75 to 0.84). Later MSFsc was significantly associated with greater insomnia and depressive symptoms after controlling for age and sex. All MCTQ parameters showed significant correlations with actigraphy-based midpoint of sleep and circadian rhythm parameters, i.e., acrophase and L5 onset (r = .362 to .619, < .01), as well as DLMO (r = .393 to .517, < .05). The associations remained significant after controlling for age. MSFsc derived from MCTQ was significantly correlated with MEQ score in both the healthy sleepers and participants with insomnia (as defined by ISI > 14), r = -.600, < .001 and r = -.543, < .001, respectively. The present study demonstrated that MCTQ is suitable for assessing chronotype with good reliability and validity in Chinese youths and supported the utility of MCTQ in individuals with insomnia.
昼夜节律类型,即个体对休息和活动时间的昼夜偏好,可以通过慕尼黑昼夜节律类型问卷(MCTQ)进行主观测量。然而,MCTQ在青少年人群中的有效性尚未得到检验。此外,MCTQ是否是失眠个体昼夜节律类型的良好测量方法仍不确定。本研究旨在验证中文版MCTQ在青少年人群中的有效性,并探讨MCTQ在失眠个体中的应用价值。原始的MCTQ采用翻译-回译法翻译成中文。本研究的第一部分包括988名青少年,他们在线完成了一系列自我报告问卷,包括用于测量昼夜节律偏好的MCTQ和晨型-夜型问卷(MEQ)、用于评估失眠症状的失眠严重程度指数(ISI)以及用于测量抑郁症状的患者健康问卷(PHQ-9)。在442名参与者中进行了为期一个月的随访,以检验重测信度。在总体样本中,随机抽取69名参与者完成研究的第二部分,其中包括为期7天的前瞻性活动记录仪监测,另有一个子集(n = 40)额外完成了基于实验室的暗光褪黑素起始(DLMO)评估,作为昼夜节律相位标记。最终,共有659名有有效回复的参与者被纳入对研究第一部分收集的数据的分析(女性 = 67.7%;平均年龄:20.7 ± 2.02)。结果显示,MCTQ参数,即自由日睡眠中点(MSF)、工作日睡眠中点(MSW)以及根据睡眠债调整后的睡眠中点(MSFsc),与MEQ得分显著相关(r = -0.514至-0.650,P < 0.01)。MCTQ的重测信度良好(组内相关系数 = 0.75至0.84)。在控制年龄和性别后,较晚的MSFsc与更严重的失眠和抑郁症状显著相关。所有MCTQ参数与基于活动记录仪的睡眠中点和昼夜节律参数,即峰值相位和L5起始,均显著相关(r = 0.362至0.619,P < 0.01),与DLMO也显著相关(r = 0.393至0.517,P < 0.05)。在控制年龄后,这些关联仍然显著。从MCTQ得出的MSFsc在健康睡眠者和失眠参与者(由ISI > 14定义)中均与MEQ得分显著相关,分别为r = -0.600,P < 0.001和r = -0.543,P < 0.001。本研究表明,MCTQ适用于评估中国青少年的昼夜节律类型,具有良好的信度和效度,并支持MCTQ在失眠个体中的应用价值。